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ProteomicsQuantitative mass spectrometry of HAX1 WT and HAX1 KO promyelocytic cells reveal differences in amino acid synthesis and lipid metabolism
part of a project: Granulocyte differentiation arrest in HAX1-deficient cells demonstrated in a new in vitro model of Kostmann disease, is caused by ineffective lipid droplet autophagy and fatty acids uptake. Molecular and metabolic mechanisms underlying congenital neutropenia in patients with HAX1 ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-22 | PXD064511 | Pride
Hax1 Lipid metabolism Lipid droplet autophagy Kostmann disease Neutrophil differentiation 
ProteomicsProteomic profile of saliva in Parkinson’s disease patients.
Parkinson’s disease (PD) is a progressive neurodegenerative disorder. Lewy pathology involves numerous organs. Submandibular glands are affected in about 75% of in vivo cases, with higher rates of positive findings in post-mortem histopathological studies. Salivary microbiome composi-tion in PD pati...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD023489 | Pride
Lc-ms-ms Parkinson disease Salivary proteom 
ProteomicsExploring extracellular vesicles of probiotic yeast Saccharomyces boulardii CNCM I-745 as carriers of biologically active molecules transferred to human intestinal cells
Extracellular vesicles (EVs) are nanoparticles containing various bioactive cargos, e.g., proteins, RNAs, and lipids, that are released into the environment by all cell types. They are involved in, amongst others, intercellular communication. This article presents studies on EVs produced by the prob...
ORGANISM(S): Saccharomyces boulardii (nom. inval.) 
2023-06-29 | PXD042660 | Pride
Doxorubicin Extracellular vesicles Saccharomyces boulardii Bioactive molecules Evs Probiotic yeasts Drug carriers 
ProteomicsThe role and cooperation of AidB dehydrogenase and AlkB dioxygenase in repair of adducts to DNA and RNA bases
The aim of the project is to conduct in vivo, in vitro and in silico studies of the substrate specificity of AidB dehydrogenase against the by-products rising in AlkB dioxygenase repair reaction and AlkB and AidB cooperative interaction in the repair of adducts to DNA and RNA bases. AidB dehydrogena...
ORGANISM(S): Escherichia coli 
2025-05-07 | PXD057294 | Pride
Aidb dehydrogenase Dna repair Alkb dioxygenase E.coli Rna repair 
ProteomicsPhosphorylation of the AP2 μ2 subunit by p70S6 kinase facilitates clathrin-mediated endocytosis.
Clathrin-mediated endocytosis (CME) internalizes cell-surface receptors via clathrin-coated invaginations of the plasma membrane. Both clathrin and endocytic cargo are recruited to these sites by the adaptor protein complex AP2. AP2 cycles between a closed cytoplasmic conformation and an open membra...
ORGANISM(S): Rattus Rattus (black Rat) 
2026-07-31 | PXD080679 | JPOST Repository
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