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TranscriptomicsColorectal tissue gene expression in SIV negative and SIV positive Rhesus macaques and sooty mangabeys
In SIV/HIV infection, the gastrointestinal tissue dominates as an important site due to the impact of massive mucosal CD4 depletion and immune activation-induced tissue pathology. Unlike AIDS-susceptible rhesus macaques, natural hosts do not progress to AIDS and resolve immune activation earlier. He...
ORGANISM(S): Macaca mulatta 
2011-09-05 | E-GEOD-29980 | biostudies-arrayexpress
TranscriptomicsMicroarray Expression Analysis of SIV infection of Sooty Mangabeys
Natural SIV infection of sooty mangabeys (SMs) does not progress to disease despite chronic virus replication. In contrast to pathogenic SIV infection of rhesus macaques (RMs), chronic SIV infection of SMs is characterized by low immune activation. To elucidate the mechanisms underlying this phenoty...
ORGANISM(S): Cercocebus torquatus atys 
2010-03-08 | E-GEOD-16147 | biostudies-arrayexpress
TranscriptomicsGene expression in the blood of SIV infected Rhesus macaques following in vivo PD-1 blockade
Hyperimmune activation is one of the strong predictors of disease progression during pathogenic immunodeficiency virus infections and is mediated in part by sustained type I interferon (IFN) signaling. Combination antiretroviral therapy suppresses hyperimmune activation only partially in HIV-infecte...
ORGANISM(S): Macaca mulatta 
2012-04-26 | E-GEOD-33933 | biostudies-arrayexpress
TranscriptomicsType I IFN responses in rhesus macaques prevent SIV transmission and slow disease progression
In acute HIV infection immune activation may provide target cells and drive virus replication, which innate immunity may limit. Thus, the net effects of inflammatory mediators, including type I interferon (IFN-I), are unclear. Here, we block IFN-I signaling during pathogenic acute SIV infection wit...
ORGANISM(S): Macaca mulatta 
2014-07-23 | E-GEOD-53690 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of rhesus macaques vaccinated with ALVAC-SIV/gp120 adjuvanted in Alum or MF59.
The Canarypox/gp120/Alum vaccines decreased the risk of HIV acquisition in humans. We demonstrate here the efficacy of this vaccine regimen also in the SIVmac251 macaque model when we used the alum but not the MF59 adjuvant. Analysis of innate and adaptive cell responses, envelope antibodies Fc prof...
ORGANISM(S): Macaca mulatta 
2016-05-29 | E-GEOD-72624 | biostudies-arrayexpress
TranscriptomicsGene expression profiling data from sooty mangabeys treated with interferon alpha
In contrast to pathogenic HIV and SIV infection of humans and macaques, SIV infection of sooty mangabeys (SMs) is typically non-pathogenic despite high virus replication. A key feature of primary SIV infection of SMs is a strong type I interferon (IFN-I) response, characterized by massive up-regulat...
ORGANISM(S): Cercocebus atys 
2012-07-09 | E-GEOD-35460 | biostudies-arrayexpress
TranscriptomicsGene expression in the blood of Live Attenuated Rev-Independent Nef¯SIV infected Rhesus macaques during acute infection
Rhesus macaques (RMs) inoculated with live-attenuated Rev-Independent Nef¯ simian immunodeficiency virus (Rev-Ind Nef¯SIV) as adults or neonates controlled viremia to undetectable levels and showed no signs of immunodeficiency over 6-8 years of follow-up. We tested the capacity of this live-atten...
ORGANISM(S): Macaca mulatta 
2013-08-09 | E-GEOD-49663 | biostudies-arrayexpress
TranscriptomicsDecreased TFR/TFH ratio in SIV-infected rhesus macaques may contribute to accumulation of TFH cells in chronic infection
T follicular helper cells (TFH) are critical for the development and maintenance of germinal centers (GC) and humoral immune responses. During chronic HIV/SIV infection TFH accumulate, possibly as a result of antigen persistence. The HIV/SIV-associated TFH expansion may also reflect lack of regulati...
ORGANISM(S): Macaca mulatta 
2015-09-02 | E-GEOD-69756 | biostudies-arrayexpress
TranscriptomicsSIV Encephalitis and Uninfected Control: Hippocampus Expression Profiles
HIV-associated dementia (HAD) is a syndrome occurring in HIV-infected patients with advanced disease that likely develops as a result of macrophage and microglial activation as well as other immune events triggered by virus in the central nervous system. The most relevant experimental model of HAD, ...
ORGANISM(S): Macaca mulatta 
2010-04-03 | E-GEOD-13824 | biostudies-arrayexpress
TranscriptomicsExpression data from rhesus macaque colon, jejunum, and lung
The mucosa that lines the respiratory and gastrointestinal (GI) tracts is an important portal of entry for pathogens and provides the frontline of immune defense against HIV infection. Using the simian immunodeficiency virus (SIV) rhesus macaque model, we have performed a comparative analysis of hos...
ORGANISM(S): Macaca mulatta 
2013-11-01 | E-GEOD-51615 | biostudies-arrayexpress
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