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ProteomicsAfBPP of Navtemadlin probes in SJSA-1 cells
Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. The selectivity of this molecule is poorly understood. So we synthesised and validated two photoactivatable clickable probes...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD058033 | Pride
Navtemadlin Sjsa-1 Afbpp 
ProteomicsWhole proteome time course experiment in SJSA-1 cells
Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. In this experiment, we test the effect of Navtemadlin treatment on protein expression in SJSA-1 cells over the course of 24 ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD058053 | Pride
Whole proteome Time course Sjsa-1 
ProteomicsComparison of SJSA-1 and MCF-7 whole proteome after Navtemadlin treatment
Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. In this experiment, we compare the whole proteme of MCF-7 and SJSA-1 cells following Navtemadlin treatment in order to gain ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD058081 | Pride
Whole proteome Navtemadlin Sjsa-1 Mcf-7 
GenomicsDatasets for the effects of RUNX2 silencing on transcriptomic and metabolomic profiles in SJSA-1 osteosarcoma cells
Datasets for the effects of RUNX2 silencing on transcriptomic and metabolomic profiles in SJSA-1 osteosarcoma cells
PRJNA667241 | ENA
ProteomicsWhole proteome experiment to validate treatment conditions in SJSA-1 cells
Navtemadlin is a potent small moeclule inhibitor of the p53-MDM2 protein-protein interaction, that is being tested in Phase II/III clinical trials for the treatment of cancer. The selectivity of this molecule is poorly understood. So we synthesised and validated two photoactivatable clickable probes...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD058047 | Pride
Sjsa-1 Whole proteome Navtemadlin 
UnknownDatasets for the effects of RUNX2 silencing on transcriptomic and metabolomic profiles in SJSA-1 osteosarcoma cells.
Not available
S-EPMC10470355 | biostudies-literature
UnknownMechanisms of peptide amphiphile internalization by SJSA-1 cells in vitro.
Not available
S-EPMC2713106 | biostudies-literature
TranscriptomicsDatasets for the effects of RUNX2 silencing on transcriptomic and metabolomic profiles in SJSA-1 osteosarcoma cells
Osteosarcoma is the most common primary malignant bone tumor with a high risk of metastasis and recurrence. Metabolic reprogramming is a hallmark of osteosarcoma and other cancers and is associated with genetic and epigenetic alterations. RUNX2 is an important transcription factor for osteoblastic d...
ORGANISM(S): Homo sapiens 
2023-06-25 | GSE158976 | GEO
UnknownStapled peptides as scaffolds for developing radiotracers for intracellular targets: Preliminary evaluation of a radioiodinated MDM2-binding stapled peptide in the SJSA-1 osteosarcoma model.
Not available
S-EPMC9940446 | biostudies-literature
ProteomicsWhole proteome characterisation following treatment with α-helix mimetic inhibitors of MDM2
A wide range of small molecule scaffolds capable of mimicking protein α-helices to modulate protein-protein interactions have been reported, yet their target selectivity is poorly understood. Here, we report the changes to the whole protoeme of SJSA-1 osteosarcoma cells following treatment with thre...
ORGANISM(S): Homo sapiens (Human) 
2026-08-05 | PXD063398 | Pride
Whole proteome Α-helix mimetics Mdm2 
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