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MetabolomicsMDM2-Dependent Rewiring of Metabolomic and Lipidomic Profiles in Dedifferentiated Liposarcoma Models
Not available
ORGANISM(S): Homo sapiens 
ST001405 | MetabolomicsWorkbench
ProteomicsMDM2 influenced chromatin-associated phospho-peptides in T47D cells
Employing a stable isotope labeling in cell culture analysis in T47D breast cancer cells (expressing mtp53 L194F), we uncovered several chromatin-associated DNA replication and repair factors as MDM2-regulated (by MDM2 inducible knock-down) phosphoproteins, including 53BP1
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD061454 | Pride
Chromatin-associated Phospho-peptides Mdm2 53bp1 
TranscriptomicsTargeting MDM4/MDM2 binding interface for reactivation of p53 in cancer therapy
The aim of this experiment has been to investigate the transcriptional profile of HCT116 cells treated with Peptide-3 (Pep3) compared to untreated (NT), treated with solvent (DMSO) or with a mutated peptide (Pep3M) cells. Peptide-3 is a dodecapeptide able to interact with MDM2 at the levels of the i...
ORGANISM(S): Homo sapiens 
2017-04-18 | E-GEOD-62855 | biostudies-arrayexpress
ProteomicsAdipose MDM2 regulates systemic insulin sensitivity through nuclear import of MORC2 and the PPARγ cofactor LIPIN1
The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in thei...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD020812 | Pride
Morc2 Obesity Pparγ C/ebp Mdm2 Lipin1 
ProteomicsProteomics Data for MDM2-targeting PROTACs in MDM2-Overexpressing HeLa Cells
Data files associated with the manuscript titled "Development of MDM2-targeting PROTAC for Advancing Bone Regeneration," which is currently under review. This manuscript introduces MDM2-targeting PROTACs specifically designed for applications in bone regeneration. We developed MDM2-PROTACs (CL144) t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-12 | MSV000097107 | MassIVE
ProteomicsMDM2 influences ACE2 stability and SARS-Cov2 uptake
The Angiotensin-converting enzyme 2 (ACE2) receptor is the central entry point for SARS-Cov2. Several SAR-Cov2 substrains have developed mutations in their spike protein to maximize their use of ACE2, e.g. to strengthen ACE2 binding for increased uptake or adapt to specific amino acid properties of ...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2023-09-08 | PXD040891 | Pride
Human Ubiquitination Sars-cov2 Ace2 
ModelsProctor2008 - p53/Mdm2 circuit - p53 stabilisation by ATM
Proctor2008 - p53/Mdm2 circuit - p53 stabilisation by ATM This model is described in the article: Explaining oscillations and variability in the p53-Mdm2 system. Proctor CJ, Gray DA. BMC Syst Biol 2008; 2: 75 Abstract: BACKGROUND: In individual living cells p53 has been...
2024-09-02 | BIOMD0000000188 | BioModels
ModelsProctor2008 - p53/Mdm2 circuit - p53 stablisation by p14ARF
Proctor2008 - p53/Mdm2 circuit - p53 stabilisation by p14ARF This model is described in the article: Explaining oscillations and variability in the p53-Mdm2 system. Proctor CJ, Gray DA. BMC Syst Biol 2008; 2: 75 Abstract: BACKGROUND: In individual living cells p53 has b...
2024-09-02 | BIOMD0000000189 | BioModels
TranscriptomicsTranscription profiling of intestine from wild type and Mdm2 knock-out mice
Analyzed gene expression in 3-day old mice lacking Mdm2 in the intestine
ORGANISM(S): Mus musculus 
2008-03-23 | E-MEXP-1431 | biostudies-arrayexpress
ProteomicsProteomics analysis of differentially expressed proteins in response to Mdm2 knockdown or treatment with Mdm2 inhibitor, MEL23
Tumor cells had Mdm2 silenced through transfection with siRNAs (two siRNAs against Mdm2 or siCtrl) or its activity inhibited through treatment with Mdm2 inhibitor, MEL23, for 24h. Total cell lysate was processed for untargeted proteomics analysis.
ORGANISM(S): Homo Sapiens (human) 
2023-05-10 | PXD033789 | JPOST Repository
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