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MetabolomicsLipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy
As a consequence of impaired glucose or fatty acid metabolism, bioenergetic stress in skeletal muscles may trigger myopathy and rhabdomyolysis. Genetic mutations causing loss of function of the LPIN1 gene frequently lead to severe rhabdomyolysis bouts in children, though the metabolic alterations an...
2019-01-07 | MTBLS750 | MetaboLights
MetabolomicsdTor affects the fat body lipidome via Nep1r1, Ctdnep1 and Lipin
Not available
ORGANISM(S): Drosophila melanogaster 
ST001859 | MetabolomicsWorkbench
UnknownLipin1 regulates PPARγ transcriptional activity.
Not available
S-EPMC3690191 | biostudies-literature
ProteomicsAdipose MDM2 regulates systemic insulin sensitivity through nuclear import of MORC2 and the PPARγ cofactor LIPIN1
The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in thei...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD020812 | Pride
Morc2 Obesity Pparγ C/ebp Mdm2 Lipin1 
UnknownLipin1 plays complementary roles in myofibre stability and regeneration in dystrophic muscles.
Not available
S-EPMC9992338 | biostudies-literature
TranscriptomicsSRSF10 regulates alternative splicing and is required for adipocyte differentiation.
During adipocyte differentiation, significant alternative splicing changes occur in association with the adipogenic process. However, little is known about roles played by splicing factors in this process. We observed that mice deficient for the splicing factor SRSF10 exhibit severely impaired devel...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-54226 | biostudies-arrayexpress
UnknownβAR-mTOR-lipin1 pathway mediates PKA-RIIβ deficiency-induced adipose browning.
Not available
S-EPMC11388065 | biostudies-literature
UnknownCompromised mitochondrial quality control triggers lipin1-related rhabdomyolysis.
Not available
S-EPMC8385327 | biostudies-literature
UnknownNAT10-mediated ac4C modification of Lipin1 mRNA contributes to the pathogenesis of PWMI.
Not available
S-EPMC12333955 | biostudies-literature
UnknownLoss of Lipin1 Contributes to Multiple Pathological Processes in the Development of Heart Failure.
Not available
S-EPMC12826883 | biostudies-literature
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