Sort   by:  
 Page size 
ProteomicsMORC2 phosphorylation fine tunes its DNA compaction activity
Variants in the poorly characterized oncoprotein, MORC2, a chromatin remodeling ATPase, lead to defects in epigenetic regulation and DNA damage response. MORC2 variants are associated with multiple cancers and neurological disorders. The C-terminal domain (CTD) of MORC2is often phosphorylated in DNA...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD053379 | Pride
Atpase Morc2 Single molecule Cryo-em Crosslinking ms Flim-fret Hdx-ms Epigenetics Ffs Chromatin remodeling 
ProteomicsIdentification and characterization of a human MORC2 DNA binding region that is required for gene silencing
The eukaryotic microrchidia (MORC) protein family are DNA gyrase, Hsp90, histidine kinase, MutL (GHKL)-type ATPases involved in gene expression regulation and chromatin compaction. The molecular mechanisms underlying these activities are incompletely understood. Here, we studied the full-length huma...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD050648 | Pride
Morc Dna Gene silencing Human 
GenomicsATAC-seq profiling of mutated MORC2 overexpression in MORC2-knocked-out HEK293T cells
ATAC-seq profiling of mutated MORC2 overexpression in MORC2-knocked-out HEK293T cells
PRJNA1193559 | ENA
GenomicsH3K9me3 and MORC2 ChIP-seq profiling of wild-type and MORC2-knock-out HEK293T cells
H3K9me3 and MORC2 ChIP-seq profiling of wild-type and MORC2-knock-out HEK293T cells
PRJNA1148458 | ENA
ProteomicsAdipose MDM2 regulates systemic insulin sensitivity through nuclear import of MORC2 and the PPARγ cofactor LIPIN1
The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in thei...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD020812 | Pride
Morc2 Obesity Pparγ C/ebp Mdm2 Lipin1 
GenomicsMORC2 promotes renal carcinogenesis via epigenetically downregulating DAPK1
MORC2 promotes renal carcinogenesis via epigenetically downregulating DAPK1
PRJNA913012 | ENA
GenomicsRNA-seq profiling of MORC2 knock-out HEK293T cells
RNA-seq profiling of MORC2 knock-out HEK293T cells
PRJNA1147784 | ENA
GenomicsATAC-seq profiling of MORC2 knock-out HEK293T cells
ATAC-seq profiling of MORC2 knock-out HEK293T cells
PRJNA1147785 | ENA
GenomicsATAC-seq profiling of MORC2 overexpression in wild-type HEK293T cells
ATAC-seq profiling of MORC2 overexpression in wild-type HEK293T cells
PRJNA1193565 | ENA
UnknownHSP90 N-terminal inhibitors target oncoprotein MORC2 for autophagic degradation and suppress MORC2-driven breast cancer progression.
Not available
S-EPMC9076019 | biostudies-literature
Sort   by:  
 Page size