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MetabolomicsMulti-omics Insights into Postnatal Skeletal Muscle Development in Duroc Pigs

Skeletal muscles, accounting for 40% of mammalian body mass, exhibit pronounced heterogeneity due to distinct anatomical locations. Animal husbandry excessively focuses on longissimus dorsi (LDM) development, while neglecting other muscles. In this study, we integrated Bulk RNA Sequencing (bulk R...

2025-09-09 | MTBLS12963 | MetaboLights
MetabolomicsMicrobiome and metabolome patterns centered on cancer cachexia link skeletal muscle and adipose tissue depletion to clinical outcomes in locally advanced rectal cancer

This study employed untargeted serum metabolomics to delineate the specific metabolic landscape of cancer cachexia in patients with locally advanced rectal cancer. By analyzing LC-MS raw data from 133 patients (64 discovery, 69 validation), we identified and validated key cachexia-associated meta...

2026-05-09 | MTBLS13787 | MetaboLights
ProteomicsBeyond Myosin Heavy Chains in Human Skeletal Muscle Heterogeneity
Skeletal muscle is an inherently heterogenous tissue comprised primarily of myofibers, which are historically classified into three distinct fiber types in humans: one “slow” (type 1) and two “fast” (type 2A and type 2X), delineated by the expression of myosin heavy chain isoforms (MYHs). However, w...
ORGANISM(S): Homo sapiens (Human) 
2025-02-27 | PXD046863 | Pride
Single muscle fiber  cell heterogeneity  myopathy  fiber type 
TranscriptomicsSingle-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. Using single nucleus RNA-sequencing (snRNAseq) of isolated nuclei from muscle fibers, we investigated nuclear heterogeneity and transcriptional dynamics in uninjured and regenerating muscle.
ORGANISM(S): Mus musculus 
2020-10-07 | E-MTAB-8623 | biostudies-arrayexpress
ProteomicsDysregulated Skeletal Muscle Myosin Super-relaxation in Type II, but Not Type I, Diabetes Mellitus
Skeletal muscle plays a critical role in the onset and development of type II diabetes. However, very few studies have investigated the potential pathogenic role of its most abundant protein, myosin. Hence, here, we aim to define this by focusing on myosin energy-saving state known as super-relaxed ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-29 | PXD053022 | Pride
Proteomics Single muscle fiber Skeletal muscle Diabetes 
TranscriptomicsCluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophy
Overall, the widely disparate transcriptomes identified prior to RT among the three clusters support the notion that at least some of the inter-individual heterogeneity in propensity for RT-induced myofiber hypertrophy is likely pre-determined. Baseline comparisons of skeletal muscle transcript prof...
ORGANISM(S): Homo sapiens 
2013-05-24 | E-GEOD-42507 | biostudies-arrayexpress
TranscriptomicsSex differences in skeletal muscle pathology in patients with heart failure and reduced ejection
Females with heart failure and reduced ejection fraction (HFrEF) have greater physical limitations and a lower quality of life compared to males, however, the role of non-cardiac mechanisms remains poorly resolved. We hypothesized that differences in skeletal muscle pathology between males and femal...
ORGANISM(S): Homo sapiens 
2024-07-12 | E-MTAB-14110 | biostudies-arrayexpress
TranscriptomicsMicrogenomic Analysis in Skeletal Muscle: Expression Signatures of Individual Fast and Slow Myofibers
Background: skeletal muscle is a complex, versatile tissue composed of a variety of functionally diverse fiber types. Although the biochemical, structural and functional properties of myofibers have been the subject of intense investigation for the last decades, understanding molecular processes reg...
ORGANISM(S): Mus musculus 
2011-07-20 | E-GEOD-23244 | biostudies-arrayexpress
TranscriptomicsBaseline skeletal muscle gene expression
Muscle biopsy samples were obtained from two groups of male subjects prior to endurance training. The samples were used to predict training responses. Baseline gene expression involving 30 probe sets was able to classify subjects into high and low responders. Resting skeletal muscle sample after an ...
ORGANISM(S): Homo sapiens 
2010-02-03 | E-GEOD-18583 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse extraocular muscle, comparison of wild type and mdx mice, 14 to 112 Days
Determination of gene expression changes in extraocular muscle of mdx (dystrophin-deficient) mice at postnatal ages 14, 28, 56, and 112 days. 3 independent replicates/age/strain. Data form part of publications: Human Molecular Genetics 12:1813-1821, 2003 and FASEB Journal 17: 893-895, 2003 (on-lin...
ORGANISM(S): Mus musculus 
2007-10-04 | E-GEOD-1008 | biostudies-arrayexpress
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