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TranscriptomicsTranscription profiling of skeleton muscles recovering at different time points after eccentric contraction and freeze-induced injury to compare the molecular events accompanying the degeneration and repair phases of muscle injuries
Common acute injuries to skeletal muscle can lead to significant pain and disability. The current therapeutic approaches for treating muscle injuries are dependent on the clinical severity but not on the type of injury. The aim of this study was to compare the molecular events accompanying the deg...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5413 | biostudies-arrayexpress
ProteomicsDefects in sarcolemma repair and skeletal muscle function after injury in a mouse model of Niemann-Pick type A/B disease
Background: Niemann-Pick disease type A (NPDA), a disease caused by mutations in acid sphingomyelinase (ASM), involves severe neurodegeneration and early death. Intracellular lipid accumulation and plasma membrane alterations are implicated in the pathology. ASM is also linked to the mechanism of pl...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-28 | PXD019356 | Pride
Mouse Injury/repair Skeletal muscle 
TranscriptomicsProfiling of mouse muscle stem cells aging and activation upon skeletal muscle injury
Utilizing glycerol intramuscular injections in M. musculus provide a models of skeletal muscle damage followed by skeletal muscle regeneration. In particular, glycerol-induced muscle injury triggers accute activation of skeletal muscle stem cells, called satellite cells. However, aging dramatically ...
ORGANISM(S): Mus musculus 
2016-07-04 | E-GEOD-81096 | biostudies-arrayexpress
TranscriptomicsModelling Skeletal Muscle Ageing and Repair In Vitro
Healthy skeletal muscle can regenerate after ischaemic, mechanical, or toxin-induced injury, but ageing impairs that regeneration potential. This has been largely attributed to dysfunctional satellite cells and reduced myogenic capacity. Understanding which signalling pathways are associated with re...
ORGANISM(S): Homo sapiens 
2023-07-05 | E-MTAB-12248 | biostudies-arrayexpress
TranscriptomicsDifferential microRNA Expression during Muscle Regeneration
MicroRNAs (miRNAs) are important in the regulation of many biological processes including muscle development. However, little is known regarding miRNA regulation of muscle regeneration. In mature murine tibialis anterior muscle following injury, 298 miRNAs were significantly changed during the time ...
ORGANISM(S): Mus musculus 
2012-04-24 | E-GEOD-37479 | biostudies-arrayexpress
TranscriptomicsDysregulated gene expression in Mef2a knockout mice subjected to cardiotoxin-induced muscle injury
We identified genes expressed in mouse skeletal muscle, during the process of muscle regeneration after injury, which are dysregulated in the absence of Mef2a expression. MEF2A is a member of the evolutionarily conserved MEF2 transcription factor family which has known roles in cardiac muscle develo...
ORGANISM(S): Mus musculus 
2013-02-12 | E-GEOD-41871 | biostudies-arrayexpress
TranscriptomicsDNA damage signaling gene array on SMA mouse skeletal muscle
A commercially available gene array (SABiosciences array PAMM-029ZD-12) was used to assay gene expression in skeletal muscle of SMA mice and control littermates. The Taiwanese severe SMA mouse model was used (Hsieh-Li et al. 2000). The array included 84 genes associated with DNA damage detection, DN...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-55481 | biostudies-arrayexpress
TranscriptomicsFTO: gene expression and function in skeletal muscle
We identified the target genes of FTO ("fat mass and obesity associated") in primary cultures of human skeletal muscle cells using adenoviral vectors expressing FTO or GFP and oligonucleotide microarrays. Human myotubes were prepared from 4 different skeletal muscle biopsies. After differe...
ORGANISM(S): Homo sapiens 
2011-07-05 | E-GEOD-22857 | biostudies-arrayexpress
TranscriptomicsSkeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing
Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The efficiency of this process declines with age contributing to neuromuscular deficits. We investigated differentially expressed genes (DEG) in muscle following peroneal nerve crush to model of motor un...
ORGANISM(S): Mus musculus 
2022-01-10 | E-MTAB-10601 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Drosophila melanogaster inoculated with P.aeruginosa or mechanically injured to investigate the skeletal muscle regulatory network in response to wound infection following trauma
Effect of injury and Pseudomonas aeruginosa inoculation in Drosophila melanogaster
ORGANISM(S): Drosophila melanogaster 
2008-01-15 | E-MEXP-1287 | biostudies-arrayexpress
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