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ProteomicsMass spectrometry-based proteomic characterization of cutaneous melanoma ectosomes reveals the presence of cancer-related molecules
Cutaneous melanoma (CM) is an aggressive type of skin cancer for which effective biomarkers are still needed. Due to the development of protocols for their successful isolation, protein content of extracellular vesicles (EVs) (including ectosomes and exosomes) became increasingly investigated in ter...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-03 | MSV000084892 | MassIVE
TranscriptomicsTranscription profiling of human tissue samples to identify novel genes associated with malignant melanoma but not benign melanocytic lesions
A number of melanoma specific genes were identified to differentiate clinical relevant tissue samples containing benign from malignant melanocytes. Experiment Overall Design: 7 normal skin, 18 nevi and 45 melanoma samples
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3189 | biostudies-arrayexpress
ProteomicsSkin cancer-associated S. aureus downregulates DNA repair mechanisms, and promotes oxidative stress and DNA damage in human keratinocytes
Actinic keratoses (AK) are premalignant lesions common on photo-damaged skin that, over time, can progress to squamous cell carcinoma (SCC). A high bacterial load of Staphylococcus aureus is associated with AK and SCC but it is unknown whether this has a direct impact on skin cancer development. To ...
ORGANISM(S): Staphylococcus Capitis Staphylococcus Aureus Staphylococcus Epidermidis Staphylococcus 
2022-05-17 | PXD031676 | panorama
TranscriptomicsExpression analysis of zebrafish melanoma and skin from the mitf-BRAFV600E;p53-/- line
Investigation of expression differences between skin and melanomas from a transgenic BRAFV600E zebrafish model of melanoma The embryos described in this study are further analyzed in a manuscript submitted for publication by White, et al. A 15 chip study using RNA extracted from either WT zebrafish ...
ORGANISM(S): Danio rerio 
2011-03-30 | E-GEOD-24528 | biostudies-arrayexpress
TranscriptomicsTargeted exome sequencing of 69 human melanoma brain metastases
In-depth information regarding the DFCI OncoPanel sequencing panel has been described previously. Briefly, sequencing is performed using an Illumina HiSeq 2500 system (RRID:SCR_016383) with 2×100 paired-end reads. Samples must meet an average 50X coverage and minimum of 30X coverage for 80% of targe...
ORGANISM(S): Homo sapiens 
2024-11-21 | E-MTAB-14575 | biostudies-arrayexpress
ProteomicsMelanopsin (OPN4) is a novel oncogene in cutaneous melanoma: evidence from an experimental study
The goal of this study was to evaluate the role of OPN4 in melanoma development using in vitro, in vivo, and proteomics approaches.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-17 | MSV000088579 | MassIVE
ProteomicsMass spectrometry based identification of similarities and differences in protein content of cutaneous melanoma cell lines and exosomes
Intercellular transport of proteins mediated by extracellular vesicles (EVs) exosomes and ectosomes, is one of the factors facilitating carcinogenesis. Therefore, the research on protein cargo of melanoma-derived EVs may provide a better understanding of mechanisms related to melanoma progression an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-15 | MSV000090907 | MassIVE
ProteomicsStromal Changes in The Aged Lung Induce an Emergence From Melanoma Dormancy
Disseminated cancer cells (DCCs) that escape the primary site can seed in distal tissues, but may take several years, or even decades to grow out into overt metastases, a phenomenon termed tumor dormancy. Despite its importance in metastasis and residual disease, few studies have been able to succes...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-03 | MSV000088977 | MassIVE
ProteomicsSpecialised skin cancer library spectral library for use in data independent mass spectrometry
A specialised spectral ion reference library for use in data independent acquisition mass spectrometry applications for the purposes of skin specific research with a particular focus on melanoma and keratinocytic carcinoma
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD025791 | Pride
Proteomics Skin Keratinocytic Carcinoma Melanoma Human 
TranscriptomicsAffymetrix expression array data for melanoma progression to the brain
Melanoma is one of the most aggressive and treatment-resistant cancers. It represents the most life-threatening neoplasm of the skin, and its incidence has been increasing for the last three decades. Melanoma evolves from the local transformation of melanocytes to primary tumors, which can metastasi...
ORGANISM(S): Homo sapiens 
2013-09-19 | E-GEOD-44660 | biostudies-arrayexpress
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