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MetabolomicsResveratrol metabolism in HepG2 (human hepatocytes), HaCaT (human keratinocytes), and C2C12 (mouse myoblasts)
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...
MTBLS127 | MetaboLights
TranscriptomicsTranscription profiling of human native skin, cultured skin substitute, constituent keratinocytes and fibroblasts to identify gene signatures that are highly characteristic of different tissue types
Cultured skin substitutes, prepared using keratinocytes, fibroblasts and biopolymers, can facilitate closure of massive burn wounds by increasing the availability of autologous tissue for grafting. However, because they contain only two cell types, skin substitutes cannot replace all of the functio...
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3204 | biostudies-arrayexpress
TranscriptomicsMicroarray of reconstructed epidermis from skin models made with cells from African and Caucasian Skin type
The aim of this study was to analyze the in vitro biological epidermal processes occurring in reconstructed skins using cells from breast skin of African and Caucasian skin type color. A exploration of mRNA expression levels in the epidermis of reconstructed skin was undertaken to elucidate the diff...
ORGANISM(S): Homo sapiens 
2020-08-10 | E-MTAB-9433 | biostudies-arrayexpress
MetabolomicsAnti-cyclooxygenase, antiglycation and anti-skin aging effect of Dendrobium officinale flowers aqueous extract and its phytochemical validation in aging

The information available in the literature concerning the beneficial effects of Dendrobium officinale flowers on the skin is limited. Therefore, the present study aimed to investigate the in vitro biological potency of its aqueous extract and screen its active components. The a...

2023-03-15 | MTBLS6933 | MetaboLights
ProteomicsSkin cancer-associated S. aureus downregulates DNA repair mechanisms, and promotes oxidative stress and DNA damage in human keratinocytes
Actinic keratoses (AK) are premalignant lesions common on photo-damaged skin that, over time, can progress to squamous cell carcinoma (SCC). A high bacterial load of Staphylococcus aureus is associated with AK and SCC but it is unknown whether this has a direct impact on skin cancer development. To ...
ORGANISM(S): Staphylococcus Capitis Staphylococcus Aureus Staphylococcus Epidermidis Staphylococcus 
2022-05-17 | PXD031676 | panorama
ProteomicsAnti-Ferroptotic Effect of Cannabidiol in Human Skin Keratinocytes Characterized by Data-Independent Acquisition-Based Proteomics
SWATH-MS data for human keratinocytes (HaCaT cell line), sample 010-012 indicates HaCaT cells with no treatment, sample 013-015 indicates HaCaT cells induced by erastin, sample 0016-018 indicates HaCaT cells treated by erastin and CBD. For more detailed information, please contact Dr.Chang Liu (hich...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-03-18 | MSV000094348 | MassIVE
TranscriptomicsAnalysis of mRNA expression differences in the skin of Casp-8F/–K5-Cre and Casp-8F/+K5-Cre mice
This SuperSeries is composed of the following subset Series: GSE17344: Analysis of spatial mRNA expression differences in the skin of Casp-8F/–K5-Cre or Casp-8F/+K5-Cre mice GSE17345: Analysis of temporal mRNA expression changes in cultured keratinocytes from Casp-8F/–K5-Cre and Casp-8F/+K5-Cre mice...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17365 | biostudies-arrayexpress
TranscriptomicsAnalysis of temporal mRNA expression changes in cultured keratinocytes from Casp-8F/M-bM-^@M-^SK5-Cre and Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17345 | biostudies-arrayexpress
TranscriptomicsmRNA expression of Atopic Dermatitis skin
mRNA array analysis was carried out using total RNA of skin biopsies from lesional and non-lesional skin of three atopic dermatitits patients and four healthy individuals.
ORGANISM(S): Homo sapiens 
2012-06-01 | E-MTAB-729 | biostudies-arrayexpress
ProteomicsProteome-wide changes in primary skin keratinocytes exposed to diesel particulate extract – a role for antioxidants in skin health
Environmental air pollution such as diesel smoke emission has been shown to have an adverse effect on human skin. Although epidemiological studies showing adverse effects such as oxidative stress-induced aging exists, studies showing the cellular and molecular response to such stress are rare. Using...
ORGANISM(S): Homo sapiens (Human) 
2018-11-06 | PXD006743 | Pride
Tocopherol Mass spectrometry Quantitative proteomics Skin keratinocytes Pollution 
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