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ProteomicsDistinct Impact of Neuronal and Astrocytic IFNAR1 Loss in Parkinson-like Dementia
Interferon-alpha/beta-receptor (IFNAR) signal defects were recently identified to contribute to sporadic Parkinson’s disease (PD) with dementia (PDD). Mice lacking interferon-beta (IFNβ) develop PDD-like disease; however, the phenotypic, cellular, and molecular impacts of IFNAR1 loss in vivo have no...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD037113 | Pride
Ifnar1 Glutamatergic neurotransmission Snrna-seq Parkinson’s disease dementia Lc-ms/ms 
ProteomicsHuntington’s disease vasculopathy is barrier-type-selective and arteriolar-dominant with spatially-coupled astrogliosis and reversible by S1pr1 stimulation
Brain vascular barriers are dysfunctional in many neurological disorders, including Huntington’s disease (HD), but which vessels are affected and how remains unclear. Using in vivo two-photon microscopy in R6/2 HD-model mice, we reveal a striking divergence in barrier dysfunction. Surface vessels of...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-14 | PXD081397 | Pride
Blood-brain barrier Huntington's disease Plasma Mouse Csf Orbitrap astral Proteomics 
ProteomicsSleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model
Impaired sleep is a common aspect of aging and often precedes the onset of Alzheimer's disease. Here, we compare the effects of sleep deprivation in young wild-type mice and their APP/PS1 littermates, a murine model of Alzheimer's disease. After 7 h of sleep deprivation, both genotypes exhibit an in...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-30 | PXD054763 | Pride
Proteomics Sleep Extracellular fluid Mouse Cerebrospinal fluid 
ProteomicsIntegrative Characterization of the R6/2 Mouse Brain Model of Huntington Disease Reveals Dysfunctional Neurotransmitter Metabolism
Huntington disease (HD) is a fatal neurodegenerative disease, where dysfunction and loss of striatal and cortical neurons are central to the pathogenesis of the disease. Here, we integrated quantitative studies to investigate the underlying mechanisms behind HD pathology in a systems-wide manner. To...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-11 | PXD008099 | Pride
Huntington disease Glutamine and glutamate metabolism High resolution lc-ms Proteome Gs-ms Glutamatergic and gabaergic neurons 
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