Sort   by:  
 Page size 
GenomicsGenome-wide occupancy map of GATA-1 in proliferating and differentiating murine ES cell derived erythroid progenitors (ES-EP)
We find GATA-1 occupies 6,600 sites in proliferating erythroid progenitors and 10,600 sites in differentiating progenitors. 80-90% of GATA-1 binds within intragenic or intergenic regions, while <20% of GATA-1 is found within 2kb of TSS. Assaying GATA-1 occupancy in normal erythroid progenitors in b...
ORGANISM(S): Mus musculus 
2012-02-27 | E-GEOD-35379 | biostudies-arrayexpress
GenomicsGenome-wide binding pattern of PU.1 in normal erythroid progenitors and erythroleukemia cells
We find that the myeloid master regulatory transcription factor, PU.1, binds to >16,000 sites in both normal and leukemic erythroid cells. Of these bound sites, ~7,000 lie within 2kb of TSS of a gene, suggesting PU.1 may regulate a large number of genes in erythroid cells. Coupling this data with ge...
ORGANISM(S): Mus musculus 
2011-06-23 | E-GEOD-21950 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of differentiating normal and leukemic erythroid progenitors
We compared the transcriptomes of differentiating cultures of ES cell derived erythroid progentor cells (ES-EP) and murine erythroleukemia (MEL) cells stably transfected with GATA-1 fused to ER. RNA was isolated from duplicate differntiating cultures of MEL and ES-EP using Affymetrix GeneChip Mouse ...
ORGANISM(S): Mus musculus 
2012-02-27 | E-GEOD-35384 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of normal erythroid progenitors and erythroleukemia cells
We compared the transcriptomes of ES cell derived erythroid progentor cells (ES-EP) and murine erythroleukemia (MEL) cells stably transfected with Gata-1 fused to ER. RNA was isolated from duplicate proliferating cultures of MEL and ES-EP using Affymetrix GeneChip Mouse Gene 1.0 ST.
ORGANISM(S): Mus musculus 
2011-06-23 | E-GEOD-21949 | biostudies-arrayexpress
TranscriptomicsAnalysis of Drosophila salivary glands and Kc cells with depleted levels of linker histone H1 (Illumina smRNA-Seq]
Salivary glands or larval ovaries were isolated from transgenic flies expressing RNAi targeting Nautilus (control) or linker histone H1 using a Tub-Gal4 driver. ~200 larvae were used to isolate salivary glands or ovaries, independently. Total RNA was isolated using Trizol reagent following manufact...
ORGANISM(S): Drosophila melanogaster 
2013-04-22 | E-GEOD-44399 | biostudies-arrayexpress
TranscriptomicsAnalysis of Drosophila salivary glands and Kc cells with depleted levels of linker histone H1 [Affymetrix Expression]
Indicated cells were subjected to RNAi against linker histone H1, Nautilus (control), or GFP (control). RNA was isolated and subjected to Affymetrix GeneChIP Drosophila Genome 2.0 arrays RNA was compared from cells treated with RNAi against control (Nautilus in the case of salivary glands or GFP in...
ORGANISM(S): Drosophila melanogaster 
2013-04-22 | E-GEOD-44398 | biostudies-arrayexpress
TranscriptomicsAnalysis of Drosophila salivary glands and Kc cells with depleted levels of linker histone H1
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2013-04-22 | E-GEOD-44148 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse erythroleukemia cells following activation of Gata1-ER or PU.1-ER transgenes
17b-Estradiol added to MEL cells expressing Gata1-ER or PU.1-ER transgenes to stimulate either erythropoietic Gata-1 dependent or myeloid PU.1 dependent gene espression in different time points
ORGANISM(S): Mus musculus 
2009-09-30 | E-MTAB-125 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Dnmt3L+/- sires compared to offspring of Dnmt3L+/+ sires to investigate the effect of paternal haploinsufficiency for Dnmt3L
There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and the early developing embryo. One corollary to this is that disruption of the establishment of epigenetic state in the gametes of a parent, ...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7384 | biostudies-arrayexpress
GenomicsH1 linker histones regulate the balance of repressive and active chromatin domains via localized genomic compaction [CUT&Tag]
H1 linker histones regulate the balance of repressive and active chromatin domains via localized genomic compaction [CUT&Tag]
PRJNA643174 | ENA
Sort   by:  
 Page size