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ProteomicsInward outward signaling in ovarian cancer: morpho-proteomics/phosphoproteomics profiling upon hypoxia and shear stress characterizes the adaptive potential of OVCAR-3 and SKOV-3 cells
With the onset of resistance, ovarian cancer cells display almost unpredictable adaptive potential. This may derive from genetic ancestry of the tumor cells and can be additionally tailored by post translational protein modifications (PTMs). The latter are profoundly shaped by the physical and chemi...
ORGANISM(S): Homo sapiens (Human) 
2022-01-13 | PXD027466 | Pride
Hypoxia Vasculogenic mimicry Fluid shear stress Morpho-metabolic adaptation Ovarian cancer 
TranscriptomicsHuman SKOV-3 cells, Input DNA vs ChIP DNA
Identification of target genes of PITX2 homeodomain transcription factor in ovary using human ovarian adenocarcinoma cells, SKOV-3 to determine the transcriptional network of PITX2. Genotypic Technology designed Custom Human Promoter 244k ChIP-on-chip Array (AMADID-019469)
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-29649 | biostudies-arrayexpress
TranscriptomicsOffect of ATP depletion on SKOV-3 cells using apyrase
The purpose of this experiment was to identify the effects of ATP depletion (using apyrase) on a metastatic ovarian carcinoma cell line (SKOV-3) and compare it to a non-treated sample. Cells were treated either with media alone or with media with apyrase during 24h. SKOV-3 cells were harvested durin...
ORGANISM(S): Homo sapiens 
2023-12-31 | E-MTAB-13598 | biostudies-arrayexpress
TranscriptomicsAffymetrix GeneChip® human gene 2.0 ST array analysis of SKOV-3 human ovarian cancer cells following siRNA knockdown of MAD2 or TLR4 compared to cells transfected with scrambled negative control siRNAs.
Both TLR4 and MAD2 are biomarkers associated with paclitaxel resistance in ovarian cancer. Therefore we performed microarray analysis following knockdown of each marker in SKOV-3 cells to gain greater insight into key downstream pathways that these biomarkers activate and also determine any potenti...
ORGANISM(S): Homo sapiens 
2020-12-06 | E-MTAB-8440 | biostudies-arrayexpress
TranscriptomicsExpression data from SKOV3 cells treated with SAHA or vehicle control
We performed a microarray experiment to assess SAHA-induced changes in expression of genes of the homologous recombination DNA repair pathway SKOV-3 ovarian cancer cells were treated with 1µM SAHA or vehicle-control (0.01% DMSO) for 6 or 24 hours, harvested and processed for RNA isolation. Data fo...
ORGANISM(S): Homo sapiens 
2014-03-19 | E-GEOD-53603 | biostudies-arrayexpress
TranscriptomicsSKOV-3TR
Human paclitaxel-resistant (SKOV-3TR) ovarian cancer cell line and the parent SKOV-3 cell line were grown in RPMI medium containing 10% fetal calf serum. The experiment was done to compare the expression differences between the parent SKOV-3 cell line and the derived SKOV-3TR cell line. Cells were ...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-2627 | biostudies-arrayexpress
TranscriptomicsEffects of Evi1 knockdown and overexpression in SKOV-3 ovarian carcinoma cells
We studied the variations of mRNA amounts after Evi1 knockdown or Flag-Evi1 overexpression in SKOV-3 cells. Despites Evi1 discovery in 1988, its recognized role as a dominant oncogene in myeloid leukemia and more recently in epithelial cancers, only a few target genes were known and it was not clear...
ORGANISM(S): Homo sapiens 
2012-01-15 | E-GEOD-25212 | biostudies-arrayexpress
ProteomicsIntegration of two in-depth proteomics approaches determines the high grade serous ovarian cancer-associated kallikrein-related peptidase 7 (KLK7) degradome
Kallikrein-related peptidase 7 (KLK7) is a serine peptidase that is over-produced in the most lethal form of ovarian cancer, called high grade serous ovarian cancer (HGSOC). To determine its underlying molecular mechanism of action, a comprehensive analysis of KLK7 degradome in the SKOV-3 cell-secre...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD003752 | Pride
Transcriptome Matrix metalloprotease Thrombospondin Protease Extracellular Degradome Substrate Omics Microenvironment Ovarian cancer High-grade serous Kallikrein-related peptidase Tumour 
UnknownProtective Effects of Nettle Tea on SKOV-3 Ovarian Cancer Cells Through ROS Production, Apoptosis Induction, and Motility Inhibition Without Altering Autophagy.
Not available
S-EPMC11507475 | biostudies-literature
GenomicsEVI1 and AP1 Interact to Transcriptionally Regulate a Feed-Forward Loop Important for Cancer Cell Proliferation and Adhesion
This SuperSeries is composed of the following subset Series: GSE25210: Genome-wide mapping of Flag-Evi1 in SKOV-3 ovarian carcinoma cells GSE25212: Effects of Evi1 knockdown and overexpression in SKOV-3 ovarian carcinoma cells GSE33724: Effects of EVI1 mild expression in HeLa cells Refer to individu...
ORGANISM(S): Homo sapiens 
2012-01-15 | E-GEOD-25213 | biostudies-arrayexpress
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