Sort   by:  
 Page size 
GenomicsNational Cancer Institute Genome-Wide Association Study of Renal Cell Carcinoma

The National Cancer Institute (NCI) genome-wide association study (GWAS) of renal cell carcinoma (RCC) was conducted to investigate common genetic variants associated with RCC risk. The GWAS includes 1,453 RCC cases and 3,531 controls of European background from 4 studies (3 cohort, 1 case-con...

phs000351.v1.p1 | EGA
UnknownNew insights from Opisthorchis felineus genome: update on genomics of the epidemiologically important liver flukes.

Background

The three epidemiologically important Opisthorchiidae liver flukes Opisthorchis felineus, O. viverrini, and Clonorchis sinensis, are believed to harbour similar potencies to provoke hepatobiliary diseases in their definitive hosts, although their populations have substantially dif...
S-EPMC6530080 | biostudies-literature
UnknownThe influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study.

Background

Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers as proxies for putative risk factors and evaluated their relation to RCC risk ...
S-EPMC6317776 | biostudies-literature
UnknownGenome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3.
We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and ...
S-EPMC3049257 | biostudies-literature
UnknownA genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23.
Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional RCC common susceptibility loci, we conducted an independent genome-wide association study (GWAS). We analyzed 533 191 single nucleotide polym...
S-EPMC3276284 | biostudies-literature
UnknownSex specific associations in genome wide association analysis of renal cell carcinoma.
Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the first sex-specific genome-wide association analysis of RCC for men (3227...
S-EPMC6777615 | biostudies-literature
UnknownGenetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.

Background

Relative telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in several studies, with conflicting findings.

Objective

We performed an analysis of genetic variants associated with leukocyte telomere l...
S-EPMC5641242 | biostudies-literature
UnknownGenome-wide association study identifies multiple risk loci for renal cell carcinoma.
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-fou...
S-EPMC5472706 | biostudies-literature
UnknownCommon colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP.
The presence of multiple (5-100) colorectal adenomas suggests an inherited predisposition, but the genetic aetiology of this phenotype is undetermined if patients test negative for Mendelian polyposis syndromes such as familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP). We inv...
S-EPMC4140766 | biostudies-literature
UnknownGlobal, regional, and national prevalence of adult overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021.
Not available
S-EPMC11920007 | biostudies-literature
Sort   by:  
 Page size