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ProteomicsProteomic and bioinformatic analysis of the nuclear intrinsically disordered proteome
Intrinsically disordered proteins (IDPs) are biologically active molecules which are involved in many cellular functions although they do not possess a defined three-dimensional structure. They are mostly signalling and regulatory proteins. This study is the first large-scale proteomic analysis of t...
ORGANISM(S): Homo sapiens (Human) 
2015-09-21 | PXD002676 | Pride
Nuclear proteome Subproteome Transcription factors Intrinsically disordered proteins 
ProteomicsMGAT3 and MGAT5 overexpression alters the protein cargo of extracellular vesicles released by metastatic melanoma cells
Extracellular vesicles (EVs) are potential non-invasive diagnostic, prognostic, and therapeutic tools. Additionally, they are important contributors to tumorigenesis. Glycosylation has been found to modulate the composition of the EV proteome, and increased amounts of beta 1,6-branched N-glycans, sy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-08 | MSV000096340 | MassIVE
ProteomicsSenescence of endothelial cells promotes phenotypic changes in adventitial fibroblasts: possible implications for vascular aging
Aging is the most important risk factor for the development of cardiovascular diseases. Senescent cells release plethora of factors commonly known as the senescence-associated secretory phenotype (SASP), which can modulate the normal function of the vascular wall. It is currently not well understood...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-13 | MSV000094069 | MassIVE
ProteomicsHyperosmolarity adversely impacts heterologous secretory protein synthesis by Yarrowia lipolytica
In this research we were interested in answering a question whether subjecting Y. lipolytica strain overproducing recombinant secretory protein (rs-Prot) to a specific, pre-optimized stress factor may enhance synthesis of the target macromolecule. Increased osmolarity (3 Osm/kg) was the primary stre...
ORGANISM(S): Yarrowia Lipolytica (ncbitaxon:4952) 
2021-10-13 | MSV000088228 | MassIVE
ProteomicsShotgun analysis of nuclear proteins from mouse brain
Nuclei were isolated from the mouse brain. Proteins were extracted with addition of Bensonase and cleaned up by acetone precipitation. Proteis were resuspended in 50 mM ammonium bicarbonate and PPS Silent Surfactant. Samples were sonicated on ice to improve the solubility of proteins, then alkylated...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000079301 | MassIVE
ProteomicsFunctional protein composition in femoral glands of sand lizards (Lacerta agilis)
Proteins are ubiquitous macromolecules displaying a vast repertoire of chemical and enzymatic functions making them suitable candidates for chemosignals used in intraspecific communication. Proteins are present in skin gland secretions of vertebrates but their identity, and especially, their functio...
ORGANISM(S): Lacerta Agilis (ncbitaxon:80427) 
2022-02-10 | MSV000088810 | MassIVE
ProteomicsChanges in the cell wall proteome of leaves in response to the high temperature stress in Brachypodium distachyon
High temperature stress leads to complex changes to plant functionality, which affects, i.a., the cell wall structure and the cell wall protein composition. In this study, the qualitative and quantitative changes in the cell wall proteome of Brachypodium distachyon leaves in response to high (40 °C)...
ORGANISM(S): Brachypodium Distachyon (ncbitaxon:15368) 
2021-04-28 | MSV000087323 | MassIVE
ProteomicsAcquisition of embryogenic competence during protoplast development of Fagopyrum
Reprogramming in protoplast cultures is a key step for acquiring embryogenic competence by dedifferentiated cells, thus leading to plant regeneration. Therefore, to better understand factors trigging the processes, this work focuses on analysing proteomes, cell wall composition and changes in the ex...
ORGANISM(S): Fagopyrum Esculentum (ncbitaxon:3617) Fagopyrum Tataricum (ncbitaxon:62330) 
MSV000095861 | MassIVE
ProteomicsProteomic analysis of renal cancer secretome
Introduction/aim: Renal cell cancer (RCC) is the most frequent kidney malignancy. Here, we aimed to analyze RCC secretome to find key molecules involved in tumor microenvironment regulation. Methods: Conditioned media from five RCC-derived cell lines (Caki-1, KIJ-265T, KIJ-308T, 786-O, and A498) and...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-02 | MSV000088490 | MassIVE
ProteomicsThiocarboxylation of Urm1 is regulated by tightly-controlled biochemical checkpoints
Ubiquitin related modifier 1 (Urm1) is a highly conserved member of the Ubiquitin-like (UBL) family of proteins. Urm1 is a key component of the eukaryotic thiolation cascade, which is responsible for introducing sulfur at U34 in several eukaryotic tRNAs. Like other UBLs, Urm1 is also able to conjuga...
ORGANISM(S): Chaetomium Thermophilum (ncbitaxon:209285) Saccharomyces Cerevisiae (ncbitaxon:4932) 
2024-02-22 | MSV000094152 | MassIVE
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