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ProteomicsQuantifying homologous proteins and proteoforms
Many proteoforms - arising from alternative splicing, post-translational modifications (PTMs), or paralogous genes - have distinct biological functions, such as histone PTM proteoforms. However, their quantification by existing bottom-up mass-spectrometry (MS) methods is undermined by peptide-specif...
ORGANISM(S): Saccharomycetales (ncbitaxon:4892) Homo Sapiens (ncbitaxon:9606) 
2017-12-22 | MSV000081857 | MassIVE
ProteomicsComposition and RNA binding specificity of metazoan RNase MRP
Mechanistic studies have revealed ribonuclease (RNase) MRP, a conserved RNA-based enzyme, is crucial for the maturation of ribosomal RNA in eukaryotes. However, the composition and RNA substrate specificity of this multisubunit ribonucleoprotein complex in higher eukaryotes remain unknown. Here, we ...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD061658 | Pride
Nepro Ribonuclease (rnase) mrp C18orf21 Ip-ms 
ProteomicsDifferential stoichiometry among core ribosomal proteins
Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its dysregulation in disease. While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs), some experiments suggest a more variable composition. Testi...
ORGANISM(S): Saccharomycetales (ncbitaxon:4892) Mus Musculus (ncbitaxon:10090) 
2015-08-28 | MSV000079280 | MassIVE
TranscriptomicsExpression time course of yeast grown in a minimal medium
Time course of exponentially growing yeast cells Time course of exponentially growing yeast cells
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-24 | E-GEOD-56773 | biostudies-arrayexpress
ProteomicsSingle-cell proteomics reveals decreased abundance of proteostasis and meiosis proteins in advanced maternal age oocytes
Single-cell proteomics analysis of human oocytes from both young and old women
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-15 | MSV000093870 | MassIVE
ProteomicsProteome asymmetry in mouse and human embryos before fate specification
Raw files of early-stage mouse and human blastomeres & mouse zygotes
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2022-05-02 | MSV000089353 | MassIVE
ProteomicsSingle cell proteomic analysis of human prefrontal cortex in Alzheimer's Disease
Here we provide a dataset of over 2000 isolated single cells from human prefrontal cortex (Brodmann area 9) from three female individuals - two Alzheimer's disease patients at distinct stages of disease progression (Braak III and VI) and one non-AD control subject (Braak 0)
ORGANISM(S): Homo sapiens (Human) 
2025-05-05 | PXD063590 | Pride
Single-cell Human Alzheimer's disease 
ProteomicsUbiquitin-Proteasome System Dyeregulation in Alzheimer's Disease Impacts Protein Abundance.
Alzheimer’s disease is a relentlessly progressive, fatal neurodegenerative disorder associated with widespread aberrant proteomic changes. The full extent of protein dysfunctions in AD and their impact on cellular physiology remains unknown. Here, we used plexDIA, a proteomic profiling approach t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-27 | PXD064265 | Pride
Alzheimer's disease Human 
ProteomicsNano ProteOmic sample Preparation nPOP_update
Update to Nano ProteOmic sample Preparation nPOP_update preprint
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088167 | MassIVE
ProteomicsData-Driven Optimization of DIA Mass-Spectrometry by DO-MS
Mass-spectrometry (MS) enables specific and accurate quantification of proteins with ever increasing throughput and sensitivity. Maximizing this potential of MS requires optimizing data acquisition parameters and performing efficient quality control for large datasets. To facilitate these objectives...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-18 | MSV000091733 | MassIVE
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