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ProteomicsSLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis
This study investigates how loss of the ER transporter SLC33A1 affects glutathione redox balance and protein cysteine reactivity in the endoplasmic reticulum. Oxidized cysteine reactivity profiling and whole-cell proteomics were performed in Slc33a1 knockout KPK cells and cDNA-complemented controls....
ORGANISM(S): Mus musculus (Mouse) 
2026-02-13 | PXD074382 | Pride
Glutathione Tmt proteomics Er redox Slc33a1 Cysteine reactivity Mouse cells Lc–ms/ms 
GenomicsKeap1 deficiency results in a genotype-specific dependency on Slc33a1
Keap1 deficiency results in a genotype-specific dependency on Slc33a1
PRJNA608860 | ENA
GenomicsSLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis [KPK_Slc33a1_KO_TUNC]
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis [KPK_Slc33a1_KO_TUNC]
PRJNA1420681 | ENA
UnknownKeap1 mutation renders lung adenocarcinomas dependent on Slc33a1.
Not available
S-EPMC8373048 | biostudies-literature
TranscriptomicsKeap1 deficiency results in a genotype-specific dependency on Slc33a1
Approximately 20-30% of human lung adenocarcinomas (LUAD) harbor loss-of-function (LOF) mutations in Kelch-like ECH Associated-Protein 1 (KEAP1), which lead to hyperactivation of the antioxidant program downstream from the nuclear factor, erythroid 2-like 2 (NRF2) transcription factor and correlates...
ORGANISM(S): Mus musculus 
2020-04-13 | GSE145945 | GEO
TranscriptomicsSLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis [KPK_Slc33a1_KO_TUNC]
Endoplasmic reticulum stress and redox homeostasis influence protein folding and unfolded protein response signaling. To examine transcriptional responses associated with Slc33a1 loss and complementation, we performed RNA sequencing of KPK cells with Slc33a1 knockout and cells complemented with eith...
ORGANISM(S): Mus musculus 
2026-02-12 | GSE318827 | GEO
UnknownS113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model.
Not available
S-EPMC5278525 | biostudies-literature
UnknownA missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42).
Not available
S-EPMC2668077 | biostudies-literature
UnknownA total of 220 patients with autosomal dominant spastic paraplegia do not display mutations in the SLC33A1 gene (SPG42).
Not available
S-EPMC2987419 | biostudies-literature
ProteomicsSLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis
The endoplasmic reticulum (ER) requires an oxidative environment to support the efficient maturation of secretory and membrane proteins. This is in part established by glutathione, a redox-active metabolite present in reduced (GSH) and oxidized (GSSG) forms. The ER maintains a higher GSSG:GSH ratio ...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-19 | PXD074465 | Pride
Tmt Mouse Lc-msms 
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