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ProteomicsCritical regulatory roles of SLFN11 on NF-kB signaling and its effects on glioblastoma growth and survival
Glioblastoma (GBM) is an aggressive and incurable brain tumor in nearly all instances, whose disease progression is driven in part by the glioma stem cell (GSC) subpopulation. Here, we explored the effects of Schlafen family member 11 (SLFN11) in the molecular, cellular and tumor biology of GBM.
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD033913 | Pride
Glioblastoma Proteomics Qe-hf 
ProteomicsProtein identification of recombinant SLFN11 and SLFN14
The Schlafen (SLFN) family of nucleic acid binding proteins play an important role in gene regulation. In response to environmental stress, many SLFN members are activated for RNA cleavage and translational regulation. To characterize the RNA cleavage activity of this protein family, we produced rec...
ORGANISM(S): Homo sapiens (Human) 
2025-07-08 | PXD064237 | Pride
Schlafen Slfn11 Slfn14 
GenomicsSLFN11 blocks stressed replication forks independently of ATR
SLFN11 blocks stressed replication forks independently of ATR
PRJNA394710 | ENA
GenomicsSLFN11 blocks stressed replication forks independently of ATR
SLFN11 sensitizes cancer cells to a broad range of DNA-targeted therapies. Here we show that, in response to replication stress induced by camptothecin, SLFN11 tightly binds chromatin at stressed replication foci via RPA1 together with the replication helicase subunit MCM3. Unlike ATR, SLFN11 neithe...
ORGANISM(S): Homo sapiens 
2018-01-18 | GSE101512 | GEO
GenomicsSLFN11 blocks stressed replication forks independently of ATR
SLFN11 sensitizes cancer cells to a broad range of DNA-targeted therapies. Here we show that, in response to replication stress induced by camptothecin, SLFN11 tightly binds chromatin at stressed replication foci via RPA1 together with the replication helicase subunit MCM3. Unlike ATR, SLFN11 neithe...
ORGANISM(S): Homo sapiens 
2018-01-18 | GSE101516 | GEO
GenomicsSLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer
SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer
PRJNA745556 | ENA
OtherSLFN11 blocks stressed replication forks independently of ATR (NS-Seq)
SLFN11 sensitizes cancer cells to a broad range of DNA-targeted therapies. Here we show that, in response to replication stress induced by camptothecin, SLFN11 tightly binds chromatin at stressed replication foci via RPA1 together with the replication helicase subunit MCM3. Unlike ATR, SLFN11 neithe...
ORGANISM(S): Homo sapiens 
2018-01-18 | GSE101515 | GEO
GenomicsChromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress [microarray]
Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress [microarray]
PRJNA588475 | ENA
GenomicsChromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress [RNA-seq_CHK1i]
Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress [RNA-seq_CHK1i]
PRJNA591707 | ENA
GenomicsChromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress [RNA-seq_CPT]
Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress [RNA-seq_CPT]
PRJNA591706 | ENA
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