Sort   by:  
 Page size 
ProteomicsProtein identification of recombinant SLFN11 and SLFN14
The Schlafen (SLFN) family of nucleic acid binding proteins play an important role in gene regulation. In response to environmental stress, many SLFN members are activated for RNA cleavage and translational regulation. To characterize the RNA cleavage activity of this protein family, we produced rec...
ORGANISM(S): Homo sapiens (Human) 
2025-07-08 | PXD064237 | Pride
Schlafen Slfn11 Slfn14 
GenomicsPlatelet RNAseq data for SLFN14 K219N patients
Pathogenic missense variants in SLFN14, which encodes an RNA endoribonuclease protein that regulates rRNA degradation, are known to cause inherited thrombocytopenia with impaired platelet aggregation and ATP secretion. Despite rather mild laboratory defects, these patients display an obvious bleedin...
EGAS00001006339 | EGA
UnknownRibosome dysfunction underlies SLFN14-related thrombocytopenia.
Not available
S-EPMC10646786 | biostudies-literature
UnknownStructural and functional characterization of human SLFN14.
Not available
S-EPMC12135189 | biostudies-literature
GenomicsTranscriptomic profiling of unsorted day-17 iPSC-derived megakaryocytic differentiation cultures carrying SLFN14 p.Q93W
Transcriptomic profiling of unsorted day-17 iPSC-derived megakaryocytic differentiation cultures carrying SLFN14 p.Q93W
PRJNA1480797 | ENA
TranscriptomicsTranscriptomic profiling of unsorted day-17 iPSC-derived megakaryocytic differentiation cultures carrying SLFN14 p.Q93W
This study investigated transcriptomic alterations associated with impaired megakaryocytic maturation in a patient-derived induced pluripotent stem cell (iPSC) model of SLFN14-related thrombocytopenia. Bulk RNA-seq was performed on iPSC-derived megakaryocytic cells from a control iPSC line and an SL...
ORGANISM(S): Homo sapiens 
2026-06-22 | GSE336171 | GEO
OtherSelective targeting of type II tRNAs underlies SLFN14-mediated translational repression and its dysregulation by thrombocytopenia-linked mutations
Schlafens (SLFNs) are interferon-inducible proteins with emerging roles in RNA metabolism and antiviral defense. SLFN14 is a ribosome-associated endoribonuclease whose pathogenic variants cause an autosomal dominant form of inherited thrombocytopenia (IT), yet the molecular basis of this disorder ha...
ORGANISM(S): Homo sapiens 
2026-02-09 | GSE310203 | GEO
UnknownSLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects.
Not available
S-EPMC4588283 | biostudies-literature
UnknownCryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage.
Not available
S-EPMC12215978 | biostudies-literature
GenomicsSelective targeting of type II tRNAs underlies SLFN14-mediated translational repression and its dysregulation by thrombocytopenia-linked mutations
Selective targeting of type II tRNAs underlies SLFN14-mediated translational repression and its dysregulation by thrombocytopenia-linked mutations
PRJNA1365269 | ENA
Sort   by:  
 Page size