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GenomicsSMN and Symmetric Arginine Dimethylation of RNAP II CTD Control Termination
The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) subunit POLR2A is a platform for modifications specifying the recruitment of factors that regulate transcription, mRNA processing, and chromatin remodeling. Here, we show that a CTD arginine residue (R1810 in human) that is conserved acr...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-73379 | biostudies-arrayexpress
ProteomicsLRP1 in Vascular Remodeling and Angiotensin Signaling
Vascular smooth muscle cells (vSMC) exert a critical role in sensing and maintaining vascular integrity. These cells abundantly express the low-density lipoprotein receptor-related protein 1 (LRP1), a large endocytic and signaling receptor that recognizes numerous ligands including ApoE-rich lipopro...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD038236 | Pride
Ace/angiotensin receptors/renin angiotensin system Smooth muscle proliferation and differentiation Vascular biology Lrp1 Tgf-β Sma remodeling Ang ii Hemodynamics Remodeling Animal models of human disease Proteomics Smooth muscle cells 
GenomicsFibro-Adipogenic Progenitor cells from murine SMA muscles are intrinsically adipogenic
Fibro-Adipogenic Progenitor cells from murine SMA muscles are intrinsically adipogenic
PRJNA1430551 | ENA
TranscriptomicsFibro-Adipogenic Progenitor cells from murine SMA muscles are intrinsically adipogenic
Spinal muscular atrophy is a neurodegenerative disorder caused by mutations in the SMN1 gene. Although classically viewed as a neurogenic disease, SMA patients exhibit poor skeletal muscle regeneration and increased fatty-fibrotic infiltration. Fibro-Adipogenic progenitors are mesenchymal precursor ...
ORGANISM(S): Mus musculus 
2026-03-05 | GSE322566 | GEO
UnknownApelin Inhibits Angiotensin II-Induced Atrial Fibrosis and Atrial Fibrillation via TGF-β1/Smad2/α-SMA Pathway.
Not available
S-EPMC7711167 | biostudies-literature
UnknownThe Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA.
Not available
S-EPMC6937140 | biostudies-literature
UnknownFAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.
Not available
S-EPMC1877111 | biostudies-literature
ProteomicsGu-Ben-Fang-Xiao decoction ameliorates airway remodeling by regulating the PI3K/AKT signaling pathway mediated by RTN4 in a chronic remission asthma murine model
Airway remodeling is a main pathological feature of asthma. The current therapy for asthma is mainly targeted for reducing inflammation, not particularly for airway remodeling. Herein, developing alternative and more effective therapy to attenuate remodeling is worthy of further study. Gu-Ben-Fang-X...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD020711 | Pride
Rtn4 Pi3k/akt pathway Gu-ben-fang-xiao decoction Chronic remission asthma Airway remodeling 
TranscriptomicsGenomic differences distinguish the myofibroblast phenotype of distal lung from airway fibroblasts
ABSTRACT Primary human distal lung/parenchymal fibroblasts (DLF) exhibit a different phenotype from airway fibroblasts (AF), including the expression of high levels of a-smooth muscle actin (a-SMA). The scope of the differences and the mechanisms driving them are unknown. To determine whether disti...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-27335 | biostudies-arrayexpress
TranscriptomicsReversible and irreversible differentiation of cardiac fibroblasts
Aim: Differentiation of cardiac fibroblasts (Fb) into myofibroblasts (MyoFb) is responsible for connective tissue buildup in myocardial remodeling. We examined reversibility of MyoFb differentiation. Methods and Results: Adult rat cardiac Fb were cultured on a plastic substratum providing mechanical...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-51824 | biostudies-arrayexpress
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