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ProteomicsLRP1 in Vascular Remodeling and Angiotensin Signaling
Vascular smooth muscle cells (vSMC) exert a critical role in sensing and maintaining vascular integrity. These cells abundantly express the low-density lipoprotein receptor-related protein 1 (LRP1), a large endocytic and signaling receptor that recognizes numerous ligands including ApoE-rich lipopro...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD038236 | Pride
Ace/angiotensin receptors/renin angiotensin system Smooth muscle proliferation and differentiation Vascular biology Lrp1 Tgf-β Sma remodeling Ang ii Hemodynamics Remodeling Animal models of human disease Proteomics Smooth muscle cells 
ProteomicsNovel role of LRP1 in the regulation of smooth muscle contractile function by regulating cytoskeletal dynamics and Ca2+ signaling.
This project contains the proteomics data for the manuscript "Novel role of LRP1 in the regulation of smooth muscle contractile function by regulating cytoskeletal dynamics and Ca2+ signaling." by Au et al.
ORGANISM(S): Mus musculus (Mouse) 
2018-10-22 | PXD007544 | Pride
Dda Lrp1 Proteomics Aorta Shotgun Cardiovascular Lc-msms 
ProteomicsLow-density lipoprotein receptor-related protein 1 (LRP1)-derived peptides protect against aggregation of LDL and cholesterol loading of vascular cells. Molecular and Cellular basis for antiatherosclerotic efficacy
LRP1 and, in particular the region that spans the C-terminal half of domain CR9 (from Gly1127 to Cys1140), named LP3, is essential for aggregated LDL internalization and human coronary vascular smooth muscle cells (hcVSMC)-cholesterol loading. Here, we investigated whether LP3 and its retro-enantio ...
ORGANISM(S): Homo Sapiens 
2021-01-23 | PXD011261 | panorama
ProteomicsGALNT11 Controlled O-glycans Modulate Ligand Interactions of the Endocytic Receptor LRP1
Low-density lipoprotein receptor (LDLR) and LDLR-related proteins (LRPs) are essential endocytic receptors and regulators of multiple physiological processes including protein reabsorption, cholesterol clearance, and neuronal protein trafficking. Previously, we identified O-GalNAc glycans within lig...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD058370 | Pride
Glycosylation Lrp1 Tmt Mass spectrometry Galnt11 
ProteomicsLow-density lipoprotein receptor-related protein 1 (LRP1)-derived peptides protect against aggregation of LDL and cholesterol loading of vascular cells. Molecular and Cellular basis for antiatherosclerotic efficacy
LRP1 and, in particular the region that spans the C-terminal half of domain CR9 (from Gly1127 to Cys1140), named LP3, is essential for aggregated LDL internalization and human coronary vascular smooth muscle cells (hcVSMC)-cholesterol loading. Here, we investigated whether LP3 and its retro-enantio ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-26 | PXD011246 | Pride
Lrp1 Proteomics Ldl Atherosclerosis 
GenomicsAlveolar type 2 cell LRP1 is needed for surfactant phospholipids and pulmonary function in mice
Alveolar type 2 cell LRP1 is needed for surfactant phospholipids and pulmonary function in mice
PRJNA1262314 | ENA
GenomicsAlveolar type 2 cell LRP1 is needed for surfactant phospholipids and pulmonary function in mice [human]
Alveolar type 2 cell LRP1 is needed for surfactant phospholipids and pulmonary function in mice [human]
PRJNA1263490 | ENA
UnknownKIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae.
Not available
S-EPMC3912526 | biostudies-literature
GenomicsEndothelium-specific depletion of LRP1 improves glucose homeostasis through the osteocalcin-IGF1R pathway [II]
Endothelium-specific depletion of LRP1 improves glucose homeostasis through the osteocalcin-IGF1R pathway [II]
PRJNA482461 | ENA
GenomicsEndothelium-specific depletion of LRP1 improves glucose homeostasis through the osteocalcin-IGF1R pathway [I]
Endothelium-specific depletion of LRP1 improves glucose homeostasis through the osteocalcin-IGF1R pathway [I]
PRJNA482455 | ENA
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