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MetabolomicsFree fatty acid generation via Rhein-induced LDL-C endocytosis accelerates biofilm infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) being key drivers of treatment failure. Here, we ana...

2026-01-06 | MTBLS13603 | MetaboLights
MetabolomicsFree fatty acid generation via Rhein-induced LDL-C endocytosis accelerates biofilm infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) being key drivers of treatment failure. Here, we analyze MRSA/CRE b...

2026-01-06 | MTBLS13611 | MetaboLights
ProteomicsLow-density lipoprotein receptor-related protein 1 (LRP1)-derived peptides protect against aggregation of LDL and cholesterol loading of vascular cells. Molecular and Cellular basis for antiatherosclerotic efficacy
LRP1 and, in particular the region that spans the C-terminal half of domain CR9 (from Gly1127 to Cys1140), named LP3, is essential for aggregated LDL internalization and human coronary vascular smooth muscle cells (hcVSMC)-cholesterol loading. Here, we investigated whether LP3 and its retro-enantio ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-26 | PXD011246 | Pride
Lrp1 Proteomics Ldl Atherosclerosis 
MetabolomicsC56BL6 BMDM stimulated with different TLRs W/O acetylated LDL (part-II)
Not available
ORGANISM(S): Mus musculus 
ST001341 | MetabolomicsWorkbench
TranscriptomicsExpression data from ARPE-19 cells treated with LDL or ox-LDL
LDL or Ox-LDL 200ug/ml, which showed no loss of viability after a 48 hour exposure, induced a physiological and pathological transcriptional response, respectively. LDL induced a downregulation of genes associated with cholesterol biosynthesis while ox-LDL induced transcriptional alterations in gene...
ORGANISM(S): Homo sapiens 
2006-09-01 | E-GEOD-5741 | biostudies-arrayexpress
ProteomicsPresence of ceramidase activity in electronegative LDL
Electronegative LDL (LDL(-)) is a minor modified fraction of human plasma LDL with several atherogenic properties. Among them, LDL(-) has increased content of bioactive lipid mediators, such as lysophosphatidylcholine (LPC), non-esterified fatty acids (NEFA), ceramide (Cer), and sphingosine (Sph), w...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD036168 | Pride
Electronegative ldl  ceramide  sphingosine  ceramidase  sphingomyelinase 
TranscriptomicsTranscription profiling of human endothelial cells UPR signature and concomitant activation of multiple signaling pathways in cells exposed to hGX sPLA2 modified LDL
We conducted a global transcriptional profiling using microarray analysis of the response of EC exposed either to native LDL or LDL-X
ORGANISM(S): Homo sapiens 
2009-12-30 | E-MEXP-2256 | biostudies-arrayexpress
TranscriptomicsExpression data of human vascular smooth muscle cells (hVSMC) in response to n-LDL and ox-LDL.
Early transcriptomic response to n-LDL and ox-LDL in human vascular smooth muscle cells (hVSMC). We used microarrays with the aim of assessing early molecular changes that induce a response in the VSMC using native and oxidized low-density lipoprotein (n-LDL and ox-LDL). For each LDL internalization...
ORGANISM(S): Homo sapiens 
2016-02-09 | E-GEOD-68021 | biostudies-arrayexpress
ProteomicsLow-density lipoprotein receptor-related protein 1 (LRP1)-derived peptides protect against aggregation of LDL and cholesterol loading of vascular cells. Molecular and Cellular basis for antiatherosclerotic efficacy
LRP1 and, in particular the region that spans the C-terminal half of domain CR9 (from Gly1127 to Cys1140), named LP3, is essential for aggregated LDL internalization and human coronary vascular smooth muscle cells (hcVSMC)-cholesterol loading. Here, we investigated whether LP3 and its retro-enantio ...
ORGANISM(S): Homo Sapiens 
2021-01-23 | PXD011261 | panorama
TranscriptomicsTranscription profiling of macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) to evaluate the gene expression profile in presence and absence of oxidized LDL
Total RNA pools from macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) were analyzed using Affymetrix oligonucleotide arrays (HGU133A) to evaluate the gene expression profile in presence and absence of oxidized LDL.
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-360 | biostudies-arrayexpress
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