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MetabolomicsMild cold exposure mitigates ischemic heart injury through indole-3-acetamide–AHR-mediated SMAD2 proteolysis

Ambient temperature profoundly influences organismal metabolism, physiology, and disease. While cold exposure is a well-recognized risk factor for the onset of myocardial infarction (MI), its impact on the injured heart after MI remains unexplored. Here,&nb...

2026-03-03 | MTBLS13965 | MetaboLights
TranscriptomicsOlig1 is a Smad cofactor involved in cell motility induced by transforming growth factor-b
Transforming growth factor (TGF)-β plays crucial roles in embryonic development and adult tissue homeostasis by eliciting various cellular responses in target cells. TGF-β signaling is principally mediated through receptor-activated Smad proteins, which regulate expression of target genes in coope...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46405 | biostudies-arrayexpress
ProteomicsConditionally reprogrammed (CRC) and feeder free SMAD inhibited (SMADi) expanded human nasal epithelial cells label-free LC-MS/MS
Discovery of therapies that are able to correct defective CFTR requires patient derived in vitro pre-clinical cell models to be developed. Two main approaches exist to expand bronchial and nasal cultures, such as conditionally reprogrammed cells (CRC) and feeder free dual SMAD inhibition (SMADi) to ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-05 | PXD018386 | Pride
Human nasal epithelial cells Cystic fibrosis Conditionally reprogrammed cells Label-free lc-ms/ms Smad inhibition 
GenomicsEnhanced cortical neural stem cell identity through SMAD/WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells
Cerebral organoids exhibit broad regional heterogeneity accompanied by limited cortical cellular diversity despite the tremendous upsurge in derivation methods, suggesting inadequate patterning of early neural stem cells (NSCs). Here we show that a short and early dual-SMAD/WNT inhibition course is ...
EGAS00001006063 | EGA
UnknownSmad inhibition by the Ste20 kinase Misshapen.
Not available
S-EPMC3131379 | biostudies-literature
ProteomicsReverse phase protein arrays (RPPAs): effects of MPS1 inhibition on signaling pathways in GBM cells
To determine the biological effects of MPS1 inhibition (both by siRNA and Drug (NMSP715)) on signaling pathways in GBM cells (U251 &U87), we profiled the modulation of phosphorylated and non-phosphorylated proteins using RPPA Relative protein levels for each sample were determined by interpolation o...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-67502 | biostudies-arrayexpress
UnknownDual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells.
Not available
S-EPMC4975684 | biostudies-literature
UnknownJNK regulates muscle remodeling via myostatin/SMAD inhibition.
Not available
S-EPMC6072737 | biostudies-literature
GenomicsDual SMAD inhibition enhances the longevity of human epididymis epithelial cells
Dual SMAD inhibition enhances the longevity of human epididymis epithelial cells
PRJNA841341 | ENA
UnknownFine-tuning of dual-SMAD inhibition to differentiate human pluripotent stem cells into neural crest stem cells.
Not available
S-EPMC8450125 | biostudies-literature
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