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TranscriptomicsNext generation sequencing of human immune cell subsets across diseases
This study compared whole transcriptome signatures of 6 immune cell subsets and whole blood from patients with an array of immune-associated diseases. Fresh blood samples were collected from healthy subjects and subjects diagnosed type 1 diabetes, amyotrophic lateral sclerosis, and sepsis, as well a...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-60424 | biostudies-arrayexpress
TranscriptomicsExpression data from proximal jejunum of WT vs. TLR2 KO mice after methotrexate (MTX) treatment
The role of innate immunity in modulating severity of chemotherapy-induced complications is so far unclear. The aim of this study was to determine how TLR2 may influence MTX-induced mucositis in the small intestine in mice. We used microarrays to assess gene expression profiles in proximal jejunum o...
ORGANISM(S): Mus musculus 
2015-01-24 | E-GEOD-56426 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profile in RAG2+ B lineage cells from the small intestinal lamina propria and RAG2+ B lineage cells from the bone marrow
We used a RAG2-GFP reporter mouse to show that RAG+ B lineage cells can be found in the small intestinal lamina proria in normally-housed mice at weaning age. We used microarry expression analysis to compare the RAG2+ population in the gut to the RAG2+ B lineage population in the bone marrow. Microa...
ORGANISM(S): Mus musculus 
2013-07-12 | E-GEOD-48805 | biostudies-arrayexpress
UnknownDevelopmental plasticity allows outside-in immune responses by resident memory T cells.
Not available
S-EPMC7096285 | biostudies-literature
TranscriptomicsMutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with renal clear cell carcinomas.
Thyroid hormone receptors (TRs) are hormone-regulated transcription factors that regulate a diverse array of biological activities, including metabolism, homeostasis, and development. TRs also serve as tumor suppressors, and aberrant TR function (via mutation, deletion, or altered expression) is as...
ORGANISM(S): Homo sapiens 
2011-05-10 | E-GEOD-29159 | biostudies-arrayexpress
MetabolomicsComparative Metabolomic Sampling of Upper and Lower Airways by Four Different Methods to Identify Biochemicals That May Support Bacterial Growth
Bacteria need nutrients from the host environment to survive, yet we know little about which biochemicals are present in the airways (the metabolome), which of these biochemicals are essential for bacterial growth and how they change with airway disease. The aims of this pilot study were to develop ...
2019-06-13 | MTBLS179 | MetaboLights
TranscriptomicsAnalysis of gene expression from fbn5-1 T-DNA insertion mutant of Arabidopsis
We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes in fbn5-1 T-DNA insertion Arabidopsis mutant. Fibrillins are lipid-associated proteins in plastids and are ubiquitous in plants. Fibrillins are known...
ORGANISM(S): Arabidopsis thaliana 
2017-04-30 | E-GEOD-68275 | biostudies-arrayexpress
GenomicsTherapeutic Targeting of Ependymoma as Informed by Oncogenic Enhancer Profiling
Genomic sequencing has driven precision-based oncology therapy; however, genetic drivers remain unknown or non-targetable for many malignancies, demanding alternative approaches to identify therapeutic leads. Ependymomas are chemotherapy-resistant brain tumours, which, despite genomic sequencing, la...
EGAS00001002696 | EGA
UnknownStructural variants are a major source of gene expression differences in humans and often affect multiple nearby genes.
Not available
S-EPMC8647827 | biostudies-literature
TranscriptomicsEffects of Ars2 or DGCR8 siRNA on gene and microRNA expression
This SuperSeries is composed of the following subset Series: GSE34679: Effects of Ars2 or DGCR8 siRNA on gene expression GSE34680: Effects of Ars2 or DGCR8 siRNA on microRNA expression Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-34681 | biostudies-arrayexpress
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