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MetabolomicsRapid chromatography combined with trapped ion mobility mass spectrometry for analysis of derivatized small molecules
Liquid chromatography (LC) separates biomolecules based on their physicochemical properties. Reproducible retention times support compound identification, while efficient separation of structurally similar compounds is essential for accurate quantification. However, conventional LC methods are often...
2026-06-30 | MTBLS14813 | MetaboLights
UnknownEvaluation of a Commercial TIMS-Q-TOF Platform for Native Mass Spectrometry.
Not available
S-EPMC11651300 | biostudies-literature
ProteomicsUltrafast and Reproducible Proteomics from Small amounts of Heart Tissue Enabled by Azo and timsTOF Pro
Data for the manuscript "Ultrafast and Reproducible Proteomics from Small amounts of Heart Tissue Enabled by Azo and timsTOF Pro".
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-21 | MSV000087476 | MassIVE
ProteomicsDevelopment of an in vitro model of Mycoplasma bovis infection in static bioreactors for proteomic investigation of small extracellular vesicles for biomarker discovery
Mycoplasma bovis (M. bovis) is a pathogenic bacterium that causes significant production and welfare issues in cattle. The dairy industry is essential to New Zealand, contributing over a quarter of the country’s total exports. Each year, ~4.7 million cows produce ~20.5 billion litres of milk, which ...
ORGANISM(S): Bos taurus (Bovine) Metamycoplasma 
2026-06-01 | PXD076118 | Pride
Proteomics Small extracellular vesicles Bioreactor Mycoplasma bovis 
ProteomicsPROTEOMIC ANALYSIS OF THE UMBILICAL CORD IN FETAL GROWTH RESTRICTION AND PREECLAMPSIA
Fetal growth restriction (FGR) is associated with adverse perinatal outcomes. Pre-eclampsia (PreE) increases the associated perinatal morbidity and mortality. The structure of the umbilical cord in the setting of FGR and PreE has yet to be determined. This study aimed to examine chan...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-15 | MSV000087051 | MassIVE
TranscriptomicsSingle cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species
Tumor-infiltrating myeloid cells (TIMs) comprise monocytes, macrophages, dendritic cells and neutrophils, and have emerged as key regulators of cancer growth. These cells can diversify into a spectrum of states, which may promote or limit tumor outgrowth, but remain poorly understood. Here, we used ...
ORGANISM(S): Homo sapiens Mus musculus 
2019-04-09 | GSE127465 | GEO
ProteomicsOnline parallel accumulation – serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer
In bottom-up proteomics, peptides are separated by liquid chromatography with elution peak widths in the range of seconds, while mass spectra are acquired in about 100 microseconds with time-of-fight (TOF) instruments. This allows adding ion mobility as a third dimension of separation. Among several...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-11-06 | PXD010012 | Pride
Tims Pasef Technological 
ProteomicsExtending the Separation Space with Trapped Ion Mobility Spectrometry Improves the Accuracy of Isobaric Tag-based Quantitation in Proteomic LC/MS/MS
Two-dimensional separation by nano-LC and trapped ion mobility spectrometry (TIMS) prior to Q-TOF tandem mass spectrometry significantly improves the accuracy of isobaric tag-based quantitation in proteome analysis without the need for additional measurement time for TIMS insertion. The obtained pea...
ORGANISM(S): Cellular Organisms 
2020-05-22 | PXD018650 | JPOST Repository
UnknownUnique Interactions of the Small Translocases of the Mitochondrial Inner Membrane (Tims) in Trypanosoma brucei.
Not available
S-EPMC10855554 | biostudies-literature
TranscriptomicsSpon1+ inflammatory monocytes promote collagen remodeling and lung cancer metastasis through lipoprotein receptor 8 signaling.
Lung cancer is the leading cause of cancer-related deaths in the world, and non-small cell lung cancer (NSCLC) is the most common subset. Although immune checkpoint inhibitors have improved outcomes in a subset of NSCLC patients, these effects are usually not durable. Thus, a more complete understan...
ORGANISM(S): Mus musculus 
2024-03-05 | GSE260524 | GEO
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