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TranscriptomicsEvidence that Loading of Cohesin Onto Chromosomes Involves Opening of Its SMC Hinge
Cohesin is a multisubunit complex that mediates sister-chromatid cohesion. Its Smc1 and Smc3 subunits possess ABC-like ATPases at one end of 50 nm long coiled coils. At the other ends are pseudosymmetrical hinge domains that interact to create V-shaped Smc1/Smc3 heterodimers. N- and C-terminal domai...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-09 | E-GEOD-4827 | biostudies-arrayexpress
GenomicsSMC translocation is unaffected by an excess of nucleoid associated proteins in vivo
SMC translocation is unaffected by an excess of nucleoid associated proteins in vivo
PRJNA1123659 | ENA
GenomicsControl of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA
Smc/ScpAB promotes chromosome segregation in prokaryotes, presumably by compacting and resolving nascent sister chromosomes. The underlying mechanisms, however, are poorly understood. Here, we investigate the role of the Smc ATPase activity in the recruitment of Smc/ScpAB to the Bacillus subtilis ch...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2016-02-18 | E-GEOD-76949 | biostudies-arrayexpress
TranscriptomicsSMC5/6 facilitates joint molecule resolution and stepwise loss of cohesin to promote meiotic chromosome segregation
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation. While meiotic functions of the cohesin and condensin complexes have been delineated, the role of the third SMC complex, Smc5/6, rema...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-27 | E-GEOD-44852 | biostudies-arrayexpress
ProteomicsSMC Complexes Are Guarded by the SUMO Protease Ulp2 Against SUMO-Chain-Mediated Turnover
Structural maintenance of chromosomes (SMC) complexes, cohesin, condensin and Smc5/6, are essential for viability and participate in multiple processes, including sister chromatid cohesion, chromosome condensation, and DNA repair. Here we show that SUMO chains target all three SMC complexes and are ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-05 | PXD022717 | Pride
Condensin Sumo chains Smc5/6 Senp/ulp proteases Cohesin Smc complexes Sumo Slx5/8 Pds5 Stubl-mediated proteasomal degradation 
TranscriptomicsCheung SMC 2011
Transcriptional profiling of origin-specific smooth muscle cells, derived from human embryonic stem cells via chemically-defined cell culture media.
ORGANISM(S): Homo sapiens 
2012-04-02 | E-MTAB-781 | biostudies-arrayexpress
TranscriptomicsFunctional analysis of TWIST1 domains regulating smooth muscle cell phenotype
TWIST1, a bHLH transcription factor, regulates mesenchymal specification, differentiation, proliferation and migration during development and in diseases such as cancer. More recently, genome-wide association studies have identified TWIST1 as a causal gene that increases risk for multiple vascular ...
ORGANISM(S): Homo sapiens 
2025-10-14 | E-MTAB-15722 | biostudies-arrayexpress
TranscriptomicsBacillus subtilis: Smc-TAP ChIP-on-chip
Genome-wide analysis of Smc distribution using ChIP-on-chip ChIP DNA versus Input DNA Keywords: ChIP-chip Combined ChIP and Input DNA from three independent experiments on single array
ORGANISM(S): Bacillus subtilis 
2010-05-19 | E-GEOD-14693 | biostudies-arrayexpress
GenomicsSMC translocation is unaffected by an excess of nucleoid associated proteins in vivo
Genome organization is important for DNA replication, gene expression, and chromosome segregation. In bacteria, two large family of proteins, nucleoid-associated proteins (NAPs) and the SMC complexes, play important roles organizing the genome. NAPs are abundant DNA-binding proteins that can bend, w...
ORGANISM(S): Bacillus subtilis PY79 
2025-01-17 | GSE269767 | GEO
TranscriptomicsTissue Factor Pathway Inhibitor-2 is Induced by Fluid Shear Stress in Vascular Smooth Muscle
Tissue Factor Pathway Inhibitor-2 is Induced by Fluid Shear Stress in Vascular Smooth Muscle Cells and Affects Cell Proliferation and Survival Introduction: Vascular smooth muscle cells (SMCs) are exposed to fluid shear stress (FSS) after interventional procedures such as balloon-angioplasty. Wher...
ORGANISM(S): Rattus norvegicus 
2010-04-12 | E-GEOD-19909 | biostudies-arrayexpress
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