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TranscriptomicsmRNA-Seq from control cells and two clones of Flp-In-T-REx-293 cells modified via CRISPR-Cas9 to knockout SMG7 in combination to knockdowns of control, SMG5, and SMG6
Mature mRNAs undergo quality control during translation that may lead to RNA degradation by triggering the nonsense mediated decay (NMD) pathway. Aberrant translation due to features such as the presence of a premature stop codon downstream on an exon-exon junction or an intron in the 3'UTR activate...
ORGANISM(S): Homo sapiens 
2021-05-07 | E-MTAB-9330 | biostudies-arrayexpress
ProteomicsNonsense-mediated mRNA decay relies on "two-factor authentication" by SMG5-SMG7
Eukaryotic gene expression is constantly regulated and controlled by the translation-coupled nonsense-mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD activation and robust clearance of NMD targets via two seemingly independent and redundant mRNA degradation branches....
ORGANISM(S): Homo sapiens (Human) 
2021-05-08 | PXD024747 | Pride
Smg6 Mrna degradation Gene expression Smg5-smg7 Nonsense-mediated mrna decay Upf1 
UnknownSMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay.
Not available
S-EPMC3553988 | biostudies-literature
TranscriptomicsGenome-wide analysis of Human Upf1, SMG5, SMG7 and PNRC2 downregulated substrates in HeLa cell
Analysis of cellular NMD (Nonsense-mediated mRNA decay) substrates that regulated by Upf1, SMG5, SMG7 and/or PNRC2 in HeLa cell. The hypothesis tested in the present study was that endogenous NMD substrates may co-regulated by Upf1, SMG5, SMG7 and PNRC2.
ORGANISM(S): Homo sapiens 
2012-11-01 | GSE34876 | GEO
UnknownSMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity.
Not available
S-EPMC8233366 | biostudies-literature
UnknownAn unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay.
Not available
S-EPMC3566313 | biostudies-literature
TranscriptomicsGenome-wide analysis of Human Upf1, SMG5, SMG7 and PNRC2 downregulated substrates in HeLa cell
Analysis of cellular NMD (Nonsense-mediated mRNA decay) substrates that regulated by Upf1, SMG5, SMG7 and/or PNRC2 in HeLa cell. The hypothesis tested in the present study was that endogenous NMD substrates may co-regulated by Upf1, SMG5, SMG7 and PNRC2. Total RNA obtained from HeLa cells with down...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-34876 | biostudies-arrayexpress
UnknownDissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells.
Not available
S-EPMC5855955 | biostudies-literature
UnknownPhospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6.
Not available
S-EPMC4132714 | biostudies-literature
GenomicsHomo sapiens
Genome-wide analysis of Human Upf1, SMG5, SMG7 and PNRC2 downregulated substrates in HeLa cell
PRJNA150109 | ENA
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