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ProteomicsCandidate disease progression biomarkers in AD
Cross-sectional and longitudinal Analysis of CSF from controls and cases with AD
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-15 | MSV000079192 | MassIVE
ProteomicsComparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype
Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently discovered that the strongest genetic risk factor for sporadic AD, apolipoprotein E epsilon 4 (APOE4), exacerbates synapse loss ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013753 | Pride
Alzheimer synapse apoe synaptoneurosome neurodegeneration 
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
UnknownDonepezil delays progression to AD in MCI subjects with depressive symptoms.
Not available
S-EPMC2697965 | biostudies-literature
UnknownFunctional and structural analyses of novel Smith-Kingsmore Syndrome-Associated MTOR variants reveal potential new mechanisms and predictors of pathogenicity.
Not available
S-EPMC8279410 | biostudies-literature
MetabolomicsOptimizing peak picking and development of a suspect screening tool for rapid annotation of the human chemical exposome from LC- HRMS datasets
The technological advances of cutting-edge high-resolution mass spectrometry (HRMS) has set the stage for a new paradigm for exposure assessment. However, it is critical to ensure that bioinformatics software developed to process raw HRMS data can disentangle low-abundant xenobiotics from the noise....
2021-01-04 | MTBLS1785 | MetaboLights
TranscriptomicsHigh-fat diet induced gene expression changes in mouse retina may be prevented by introducing bilberries in diet
Obesity and diabetes associated visual impairment and vascular dysfunctions are increasing reasons for vision loss. The detailed mechanisms in these diseases are still largely unknown, but mice models have been useful to study these mechanisms and explore the detailed effects of potential compounds....
ORGANISM(S): Mus musculus 
2012-09-08 | E-GEOD-34154 | biostudies-arrayexpress
GenomicGenetics Consortium for Late Onset of Alzheimer's Disease (LOAD CIDR Project)

Multiplex Family Study
The purpose of the NIA Genetics Initiative: Multiplex Family Study is to identify families with multiple members diagnosed with late-onset Alzheimer's Disease. Families will be characterized clinically and blood samples will be collected to establish cell...

phs000160 | dbGaP
TranscriptomicsCortical hypermethylation across an extended region spanning the HOXA gene cluster on chromosome 7 is robustly associated with Alzheimer's disease neuropathology
Alzheimer's disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. We undertook an epigenome-wide association study across three independent brain tissue cohorts (total n = 999) to identify differential DNA methylation associated with neuropatholo...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-80970 | biostudies-arrayexpress
TranscriptomicsNormal Lung + Lung adenocarcinoma microarray
Gene transcription in a set of 49 human primary lung adenocarcinomas and 9 normal lung tissue samples was examined using Affymetrix GeneChip technology. We aimed to investigate differential gene expression between the two tissue types. A total of 3,442 genes, called the set MAD, were found to be eit...
ORGANISM(S): Homo sapiens 
2005-12-31 | E-MEXP-231 | biostudies-arrayexpress
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