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ProteomicsGlobal Protein Abundance and Phosphorylation Analyses of Influenza A Virus (IAV)-Infected Human Cells
Influenza A Virus (IAV) is a recurring respiratory virus with antiviral therapies of limited use. Understanding host proteins essential for IAV infection can identify targets for alternative host-directed therapies (HDTs). Using affinity purification-mass spectrometry and global phosphoproteomic and...
ORGANISM(S): Homo sapiens (Human) 
2023-07-25 | PXD035900 | Pride
Human H5n1 H1n1 Protein abundance Phosphorylation Nhbe H3n2 Thp-1 Infection Influenza a virus 
UnknownProgression of myopia and high myopia in the Early Treatment for Retinopathy of Prematurity study: findings at 4 to 6 years of age.

Purpose

To report the prevalence of myopia and high myopia in children <6 years of age born preterm with birth weights <1251 g who developed high-risk prethreshold retinopathy of prematurity and who participated in the Early Treatment for Retinopathy of Prematurity trial.

Methods

Surv...
S-EPMC3725578 | biostudies-literature
UnknownGenome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up replication analyses in 876 cases and 1,890 controls. We confirmed association with TERT at 5p15, MUC5B at 11p15...
S-EPMC3677861 | biostudies-literature
UnknownGenome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia.

Background

Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases with largely unknown etiology and without definitive treatment other than lung transplant to prolong life. There is strong evidence for the importance of both rare and common genetic risk alleles...
S-EPMC4895966 | biostudies-literature
UnknownMultisystem Inflammatory Syndrome in U.S. Children and Adolescents.

Background

Understanding the epidemiology and clinical course of multisystem inflammatory syndrome in children (MIS-C) and its temporal association with coronavirus disease 2019 (Covid-19) is important, given the clinical and public health implications of the syndrome.

Methods

We cond...
S-EPMC7346765 | biostudies-literature
UnknownMultisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes.

Background

The assessment of real-world effectiveness of immunomodulatory medications for multisystem inflammatory syndrome in children (MIS-C) may guide therapy.

Methods

We analyzed surveillance data on inpatients younger than 21 years of age who had MIS-C and were admitted to 1 of 5...
S-EPMC8220972 | biostudies-literature
UnknownPCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.

Background

Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2...
S-EPMC5266795 | biostudies-literature
UnknownEffectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents.

Background

The increasing incidence of pediatric hospitalizations associated with coronavirus disease 2019 (Covid-19) caused by the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United States has offered an opportunity to assess the real-wor...
S-EPMC8781318 | biostudies-literature
UnknownMaternal Vaccination and Risk of Hospitalization for Covid-19 among Infants.

Background

Infants younger than 6 months of age are at high risk for complications of coronavirus disease 2019 (Covid-19) and are not eligible for vaccination. Transplacental transfer of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after maternal Covid-19 v...
S-EPMC9342588 | biostudies-literature
UnknownBNT162b2 Protection against the Omicron Variant in Children and Adolescents.

Background

Spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (omicron) variant, which led to increased U.S. hospitalizations for coronavirus disease 2019 (Covid-19), generated concern about immune evasion and the duration of protection from vaccines in chil...
S-EPMC9006785 | biostudies-literature
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