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MetabolomicsA Multi-Omic View of Host-Pathogen-Commensal Interplay in Salmonella-Mediated Intestinal Infection
The potential for commensal microorganisms indigenous to a host (the microbiome or microbiota) to alter infection outcome by influencing host-pathogen interplay is largely unknown. We used a multi-omics systems approach, incorporating proteomics, metabolomics, glycomics, and metagenomics, to explore...
2014-06-24 | MTBLS96 | MetaboLights
MetabolomicsUntargeted metabolomics profiling reveals exercise intensity-dependent alterations in Thoroughbred racehorses’ plasma after routine conditioning sessions

Thoroughbred (TB) racehorses are subjected to rigorous conditioning programs involving exercise sessions of various types, distances and intensities. These programs aim to optimize both their physical and mental capabilities, which are essential to achieve maximal performance. Conventional invest...

2024-01-16 | MTBLS8285 | MetaboLights
MetabolomicsProteomic and metabolomic profiling of extracellular vesicles produced by human gut archaea

Gastrointestinal bacteria interact with the host and each other through various mechanisms, including the production of extracellular vesicles (EVs). However, the composition and potential roles of EVs released by gut archaea are poorly understood. Here, we study EVs produced by four strains of h...

2025-07-01 | MTBLS12422 | MetaboLights
ProteomicsKinome profiling of venetoclax-resistant wild type and NRAS-G12C MOLM-14 cells
Despite efficacy of FLT3 and BCL2 inhibition in acute myeloid leukemia (AML), relapse limits survival. Mutation status and AML monocytic differentiation are implicated in resistance. On-treatment tumor evolution may select for genetically distinct clones or shifts in differentiation not resolvable ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD068585 | Pride
Venetoclax Gilteritinib Kinase Inhibitor Bead Aml 
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
TranscriptomicsMapping the Genetic Architecture of Gene Expression in Human Liver
To uncover the genetic determinants affecting expression in a metabolically active tissue relevant to the study of obesity, diabetes, atherosclerosis, and other common human diseases, we profiled 427 human liver samples on a comprehensive gene expression microarray targeting greater than 40,000 tran...
ORGANISM(S): Homo sapiens 
2008-05-07 | E-GEOD-9588 | biostudies-arrayexpress
MetabolomicsMetabolomic signatures discriminate horses with clinical signs of atypical myopathy from healthy co-grazing horses
Atypical myopathy (AM) is a severe rhabdomyolysis syndrome that occurs in grazing horses. Despite the presence of toxins in their blood, all horses from the same pasture are not prone to display clinical signs of AM. The objective of this study was to compare the blood metabolomic profiles of horses...
2021-08-31 | MTBLS2579 | MetaboLights
TranscriptomicsTesting of the physiological microarray for Calanus finmarchicus by using experimental and field collected samples
Physiological changes in response to environmental cues are not easily documented in pelagic copepods using traditional methods. Molecular biological tools provide new approaches to the investigation of difficult to sample organisms such as oceanic zooplankton. Here, we describe the development of...
ORGANISM(S): Calanus finmarchicus 
2012-03-23 | E-GEOD-34322 | biostudies-arrayexpress
ProteomicsQuantitative analysis of non histone lysine methylation sites and lysine demethylases in breast cancer cell lines
Tandem Mass Tag labeling (TMT labels) based mass spectrometry was used to quantify lysine methylation from four different cell lines (n=4 replicates): MCF7 (ER positive breast cancer), MDAMB231 (TNBC), HCC1806 (TNBC), and MCF10A (non-cancerous), sans antibody enrichment. To boost the detection of ly...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-24 | MSV000095132 | MassIVE
ProteomicsProteomic analysis of mitochondrial regulation of the 26S proteasome
The proteasome is the main proteolytic system for targeted protein degradation in the cell. Its function is fine-tuned according to cellular needs. Inhibition of the respiratory chain impairs proteasome activity, regulation of proteasome function by mitochondrial metabolism, however, is unknown. He...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-16 | PXD019695 | Pride
26s proteasome Respiratory complex i Mitochondria Proteasome assembly factors Pyruvate Metabolic reprogramming Aspartate 
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