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TranscriptomicsTranscriptional changes in IL-2, IL-12 and IL-18 stimulated human natural killer cells
We used Affymetrix expression arrays to determine changes in gene expression associated with activation of human NK cells mediated through treatment with cytokines IL-2, IL-12 and IL-18 over a 24 hour period. Human natural killer cells were isolated via negative selection from PBMCs of healthy donor...
ORGANISM(S): Homo sapiens 
2010-08-05 | E-GEOD-22919 | biostudies-arrayexpress
MetabolomicsRegional HNSCC metabolomics reveals widespread changes to one-carbon metabolism and S-adenosylmethionine metabolism across tumour core, tumour edge and adjacent non-tumour tissues

Cancer, including head and neck squamous cell carcinoma (HNSCC), induces changes to metabolism that drive the disease. Regional metabolomics can help to understand metabolic variation across the tumour including changes near the tumour core, where hypoxia is likely more pronounced. We apply ultra...

2026-06-03 | MTBLS1905 | MetaboLights
ProteomicsDAPK3 modulates migration and invasion of triple negative breast cancers
A mass spectrometry (MS)-based kinase inhibitor pulldown assay (KIPA) was applied to analyze 16 patient-derived xenografts (PDXs) leading to the discovery that Death-Associated Protein Kinase 3 (DAPK3) is significantly and specifically overexpressed in triple negative breast cancer (TNBC). Validatio...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049187 | Pride
Luzp1 Emt Breast cancer Cancer Dapk3 Pdx 
TranscriptomicsZfx controls BCR-induced proliferation and survival of B lymphocytes
The development, homeostasis and function of B lymphocytes involve multiple rounds of B cell receptor (BCR)-controlled proliferation and prolonged maintenance. We analyzed the role of transcription factor Zfx, a recently identified regulator of stem cell maintenance, in B cell development and homeos...
ORGANISM(S): Mus musculus 
2009-04-16 | E-GEOD-13547 | biostudies-arrayexpress
ProteomicsPACS1 syndrome variant alters proteomic landscape of developing cortical organoids
Several large-scale genetic studies investigating the cause of neurodevelopmental disorders (NDDs) have been conducted, leading to the identification of hundreds of risk genes. However, our understanding of the mechanisms by which the observed genetic variants act has lagged, limiting translation of...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD080130 | Pride
Pacs1 Proteome Neurodevelopmental disorders Brain organoids 
TranscriptomicsTranscription profiling of Lotus japonicus grown under different salt acclimation regimes
Model legume Lotus japonicus was subjected to non-lethal long-term salinity and profiled at the transcriptomic level. Three independent experiments were performed, testing two experimental designs: a traditional gradual acclimation following a step-wise increase of salt concentration and an initial ...
ORGANISM(S): Lotus japonicus 
2008-07-17 | E-MEXP-1204 | biostudies-arrayexpress
ProteomicsThe Perijunctional Zone Is a Molecularly Distinct Muscle Subdomain Altered in Duchenne Muscular Dystrophy
The neuromuscular junction (NMJ) is a well-established model for synapse development, structure, and function. Surrounding the NMJ is a narrow perijunctional zone (PJZ), enriched in muscle-specific voltage-gated sodium channels that prevent synaptic fatigue. Despite this role, the PJZ remains poorly...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-27 | PXD067080 | Pride
Muscle proteomics Perijunctional zone Perilipin 4 Turboid Proximity labelling Duchenne muscular dystrophy Neuromuscular junction 
MetabolomicsSPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids
Characterization of endogenous metabolites and xenobiotics is essential to deconvoluting the genetic and environmental causes of disease. However, surveillance of chemical exposure and disease-related changes in large cohorts requires an analytical platform that offers rapid measurement, high sensit...
2017-02-14 | MTBLS427 | MetaboLights
MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
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