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TranscriptomicsTranscription profiling of 4 week old BALB/c_Fech m1Pas mice (Fech) vs with 4 week old control BALB/c mice
Comparison of liver gene expression of 4 week old BALB/c_Fech m1Pas mice(Fech mice for short) with 4 week old control BALB/c mice.
ORGANISM(S): Mus musculus 
2005-10-21 | E-MEXP-194 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human donor-matched retinal and choroidal vascular endothelial cells
Consistent with clinical observations that posterior uveitis frequently involves the retinal vasculature and recent recognition of vascular heterogeneity, we hypothesized that retinal vascular endothelium was a cell population of unique molecular phenotype. Donor-matched cultures of primary retinal ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7850 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skin carcinogenesis in FVB/N and Tg.Ac mice
Female FVB/N and Tg.Ac (hemizygotes) mice 3-5 weeks of age were purchased from Harlan UK and Taconic UK, respectively. The mice were contained in an isolator and maintained at 19C with 50% relative humidity and a 12-hour light-dark cycle. Following a 1 week acclimatisation period the dorsal skin o...
ORGANISM(S): Mus musculus 
2005-10-01 | E-MEXP-188 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung from wildtype and glucocorticoid recepter knockouts to investigate investigate the role of glucocorticoids in fetal lung development
The aim of this experiment is to investigate the role of glucocorticoids in fetal lung development in more detail.
ORGANISM(S): Mus musculus 
2007-05-31 | E-MEXP-861 | biostudies-arrayexpress
TranscriptomicsThe Relationship between Virus Replication and Host Gene Expression in Lymphatic Tissue during HIV-1 Infection
During HIV-1 infection, there is a massive perturbation of host gene expression, but as yet, genome-wide studies have not identified host genes affecting HIV-1 replication in lymphatic tissue, the primary site of virus-host interactions. In this study, we isolated RNA from the inguinal lymph nodes ...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-21589 | biostudies-arrayexpress
UnknownPhenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations.
Not available
S-EPMC8488020 | biostudies-literature
TranscriptomicsGenome-wide copy number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma
We studied 277 lymphoma samples (198 FL and 79 transformed FL [tFL]) using a single-nucleotide polymorphism array to identify the secondary chromosomal abnormalities that drive the development of FL and its transformation to diffuse large B-cell lymphoma. Affymetrix 250K NspI SNP arrays were perform...
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-67385 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of mutant and WT HNF4alpha hepatic progenitor stage cells
During mammalian development, liver differentiation is driven by signals which converge on multiple transcription factor networks. The hepatocyte nuclear factor signalling network is known to be essential for hepatocyte specification and maintenance. In these studies we demonstrate that nuclear HNF4...
ORGANISM(S): Homo sapiens 
2019-10-31 | E-MTAB-7951 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by high throughput sequencing of pancreatic islets from R299Q AMPK gamma 2 knock-in mice
RNA-Seq to investigate significant transcriptional differences underlying the defective glucose-stimulated insulin secretion of R299Q AMPK g2 knock-in mice compared to wild-type littermate controls.
ORGANISM(S): Mus musculus 
2016-05-20 | E-MTAB-3938 | biostudies-arrayexpress
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
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