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TranscriptomicsTranscription profiling of human aortic smooth muscle cells exposed to hypoxia
Systemic arterial smooth muscle cells are exposed to a broad range of oxygen concentrations under physiological conditions. Hypoxia can modulate the proliferative response of smooth muscle cells leading to speculation about its role in vasculogenesis, vascular remodelling and the pathogenesis of ar...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4725 | biostudies-arrayexpress
TranscriptomicsEffects of knockdown of ROCK1 and ZIPK on gene expression in cultured human vascular smooth muscle cells
Rho-associated kinase (ROCK) and zipper-interacting protein kinase (ZIPK) have been implicated in diverse physiological functions, including smooth muscle contraction, cell proliferation, cell adhesion, apoptosis, cell migration and inflammation. Many aspects of regulation via ROCK and ZIPK, however...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-56819 | biostudies-arrayexpress
TranscriptomicsPhenotype modulation of VSMCs on patterned substrate
Loss of contractility and acquisition of an epithelial phenotype of vascular smooth muscle cells (VSMCs) are key events in proliferative vascular pathologies such as atherosclerosis and post-angioplastic restenosis. There is no proper cell culture system allowing VSMC differentiation so that it is d...
ORGANISM(S): Rattus norvegicus 
2013-11-14 | E-MTAB-1888 | biostudies-arrayexpress
TranscriptomicsSmooth Muscle Cells
This set contains 68 arrays of two series of experiments. 60 arrays are used to profile the heterogeneity of SMCs from different anatomic locations. 8 arrays are used to profile the change of gene expression of vascular smooth muscle cells upon serum exposure. An all pairs experiment design type is ...
ORGANISM(S): Homo sapiens 
2007-09-27 | E-GEOD-7195 | biostudies-arrayexpress
TranscriptomicsFungenES: FunGenES_UKOE-4: Functional characterization and transcriptome analysis of embryonic stem cells-derived contractile smooth muscle cells
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the EuropeanUnion, http://www.fungenes.org). The experiment was conducted at University of Cologne, Cologne, Germany. Goal of the experiment is a...
ORGANISM(S): Mus musculus 
2011-02-25 | E-TABM-1123 | biostudies-arrayexpress
TranscriptomicsFunctional analysis of TWIST1 domains regulating smooth muscle cell phenotype
TWIST1, a bHLH transcription factor, regulates mesenchymal specification, differentiation, proliferation and migration during development and in diseases such as cancer. More recently, genome-wide association studies have identified TWIST1 as a causal gene that increases risk for multiple vascular ...
ORGANISM(S): Homo sapiens 
2025-10-14 | E-MTAB-15722 | biostudies-arrayexpress
TranscriptomicsDifferential microRNA Expression during Muscle Regeneration
MicroRNAs (miRNAs) are important in the regulation of many biological processes including muscle development. However, little is known regarding miRNA regulation of muscle regeneration. In mature murine tibialis anterior muscle following injury, 298 miRNAs were significantly changed during the time ...
ORGANISM(S): Mus musculus 
2012-04-24 | E-GEOD-37479 | biostudies-arrayexpress
TranscriptomicsEffect of interleukin-1 and PDGF-DD on SMCs
This experiment tests the hypothesis that interleukin-1 promotes SMC phenotypic modulation to a distinct inflammatory state relative to the growth factor PDGF-DD. Cultured rat aortic smooth muscle cells were treated with IL-1b (2.5 ng/mL) or vehicle (0.1% BSA and 10 mM acetic acid) or PDGF-DD (30 ng...
ORGANISM(S): Rattus norvegicus 
2012-05-02 | E-GEOD-31080 | biostudies-arrayexpress
TranscriptomicsA Pitx2-miRNA pathway modulates cell proliferation in myoblasts and skeletal-muscle satellite cells and promotes their commitment to a myogenic cell fate.
The acquisition of a proliferating cell status from a quiescent state as well as the shift between proliferation and differentiation are key developmental steps in skeletal-muscle stem cells (satellite cells) to provide proper muscle regeneration. However, how satellite-cell proliferation is regulat...
ORGANISM(S): Mus musculus 
2015-06-10 | E-GEOD-53943 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of jejunums from wild type and Klf9-/- mice to investigate the involvement of Klf9 in small intestine crypt-villus cell renewal and lineage determination.
Kruppel-like factor 9 (Klf9), a zinc-finger transcription factor, is implicated in the control of cell proliferation, cell differentiation and cell fate in brain and uterus. Using Klf9 null mutant mice, we have investigated the involvement of Klf9 in small intestine crypt-villus cell renewal and li...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6443 | biostudies-arrayexpress
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