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ProteomicsFibroblast-derived Smoothened governs prognosis of acute kidney injury
Although the tubule is the epicenter of damage, kidney fibroblast is increasingly appreciated in governing the prognosis of acute kidney injury (AKI). Smoothened (Smo), a heptahelical transmembrane protein, carries a hedgehog signal to mediate the communications between kidney fibroblasts and tubula...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-23 | MSV000088609 | MassIVE
TranscriptomicsOncogenic mutation in Smoothened causes severe cerebellar developmental defects and medulloblastoma in mice
Deregulated developmental processes in the cerebellum cause medulloblastoma, the most common malignant tumor of the central nervous system. About 20-30% of cases are caused by mutations increasing the activity of the Sonic hedgehog (Shh) pathway, a critical mitogen in cerebellar development. The pro...
ORGANISM(S): Mus musculus 
2012-11-02 | E-GEOD-34593 | biostudies-arrayexpress
TranscriptomicsTargeting resistance to Smoothened antagonists by inhibiting the PI3K pathway
Mutations in Hedgehog (Hh) pathway genes, leading to constitutive activation of Smoothened (Smo), occur in sporadic medulloblastoma, the most common brain cancer in children. Antagonists of Smo induce tumor regression in mouse models of medulloblastoma and hold great promise for targeted therapy fo...
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-19657 | biostudies-arrayexpress
ProteomicsSmoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Subunits
The Hedgehog (Hh) pathway is essential for tissue homeostasis, and misregulation of this cascade drives several cancers. To control expression of pathway target genes, the G protein-coupled receptor (GPCR) Smoothened (SMO) activates glioma-associated (GLI) transcription factors via an unknown mechan...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-25 | PXD019346 | Pride
Smoothened Phosphorylation 
TranscriptomicsGene expression profiling of constitutive activation of Smoothened in the mouse uterus
In order to gain a better understanding of Ihh action during embryo implantation, we constitutively activated Smo in the murine uterus using the PRcre mouse model (PRcre/+SmoM2+; SmoM2). Female SmoM2 mice were infertile. They exhibited normal serum progesterone levels and normal ovulation, but ova ...
ORGANISM(S): Mus musculus 
2010-04-13 | E-GEOD-17263 | biostudies-arrayexpress
TranscriptomicsMethylation profiling data from medulloblastoma tumor samples
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large coh...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-49377 | biostudies-arrayexpress
TranscriptomicsMethylation data from medulloblastoma tumor samples
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large coh...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-49576 | biostudies-arrayexpress
GenomicsTargeting Hedgehog pathway by Smoothened Antagonist
Targeting Hedgehog pathway by Smoothened Antagonist
PRJNA720577 | ENA
TranscriptomicsTranscription profiling of mouse medulloblastomas from Cxcr6 mutant animals respond to treatment with a Smoothened inhibitor
Study of mouse medulloblastoma in response to inhibitor of Smoothened. Experiment Overall Design: Several signal array comparisons are used to supplement other forms of data. There are insufficent replicates for a statistical treatment.
ORGANISM(S): Mus musculus 
2008-04-06 | E-GEOD-7212 | biostudies-arrayexpress
TranscriptomicsHedgehog pathway inhibition in chondrosarcoma using the Smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth
Mice bearing primary human chondrosarcoma xenografts were treated with IPI 926, and mRNA levels of known Hh pathway genes and endpoint tumor volumes were measured. Gene expression profiling of IPI-926 treated tumors was conducted to identify potential novel Hh target genes. 4 Control treated and 4 I...
ORGANISM(S): Homo sapiens 
2014-03-18 | E-GEOD-44581 | biostudies-arrayexpress
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