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TranscriptomicsTranscription profiling of human embryonic kidney cells overexpressing SMYD2 to identify which genes are regulated by SMYD2 through its histone lysine methylation activity
Identification of SMYD2 target genes - The objective of this aim is to identify which genes are regulated by SMYD2 through its histone lysine methylation activity. It is well established that post-translational modification of nucleosomal histones (H2A, H2B, H3 and H4), such as methylation, acetyla...
ORGANISM(S): Homo sapiens 
2008-02-05 | E-MEXP-963 | biostudies-arrayexpress
ProteomicsQuantitative profiling of the enzymatic activity of the protein lysine mono-methyltransferase SMYD2 using SILAC-based proteomics
The significance of non-histone lysine methylation in cell biology and human disease is an emerging area of research exploration, and small molecule inhibitors that selectively and potently target “writers” and “erasers” of methyl-lysine, such as the protein lysine mono-methyltransferase SMYD2, are ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080785 | MassIVE
ProteomicsQuantitative profiling of the enzymatic activity of the protein lysine mono-methyltransferase SMYD2 using SILAC-based proteomics
The significance of non-histone lysine methylation in cell biology and human disease is an emerging area of research exploration, and small molecule inhibitors that selectively and potently target “writers” and “erasers” of methyl-lysine, such as the protein lysine mono-methyltransferase SMYD2, are ...
ORGANISM(S): Homo sapiens (Human) 
2016-01-11 | PXD002405 | Pride
Methylation Lysine methyltransferase Silac Immunoaffinity enrichment Smyd2 
TranscriptomicsThe effects of SMYD2 overexpression on ectopic RB in SAOS cells
Expression analysis of wild-type SAOS cells and SAOS cells transiently transfected with RB, SMYD2, or RB and SMYD2. Four samples of wild-type, rb1, smyd2 and rb1-smyd2 were analyzed on the Human Genome U133 Plus 2.0 array.
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-22842 | biostudies-arrayexpress
ProteomicsDetection of CHMP2B methylation
Characterization of CHMP2B methylation by the lysine methyl transferase SMYD2 : identification of the lysine methylated by SMYD2
ORGANISM(S): Homo sapiens (Human) 
2024-03-18 | PXD041760 | Pride
Lysine methylation 
GenomicsSMYD2 overexpression in Neonatal rat ventricular cardiomyocytes
SMYD2 overexpression in Neonatal rat ventricular cardiomyocytes
PRJNA1077925 | ENA
TranscriptomicsSMYD2 specificly regulate BIX-01294 induced TP53 target genes revealed by RNA-Seq
We characterized expression profilings of SMYD2 knockdown and control cells treated by BIX-01294 and Rapamycin. We used siRNAs to knockdown SMYD2 in HCT116 cells, and NC as control. We treated those cell lines with BIX-01294 and Rapamycin, and the expression profilings were perfomed by Illumina high...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-61255 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human HT-29 WT and SMYD2-KO xenograft implanted into the flanks of Rag1−/− mice
Our data suggested that SMYD2 deficiency sensitized cells to apoptosis and necroptosis.To further narrow down the mechanism of cell death induction upon SMYD2 deficiency, RNA-seq analysis was performed on implanted tumor tissues from two clones of SMYD2 deficient and WT HT-29 cells.
ORGANISM(S): Homo sapiens 
2021-10-18 | E-MTAB-11053 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse heart from mice with a SMYD2 heart-specific deletion
Effect of Smyd2 cardiac deficiency was analyzed in mouse heart
ORGANISM(S): Mus musculus 
2010-04-12 | E-MEXP-2542 | biostudies-arrayexpress
GenomicsChip-chip from MDA-MB-231 cells with SMYD2 and EZH2
Chip-chip from MDA-MB-231 cells with SMYD2 and EZH2
PRJNA520883 | ENA
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