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ProteomicsRoles of SNORD115 and SNORD116 ncRNA clusters in neuronal differentiation
Prader-Willi syndrome shows features linked to brain development and hypothalamus-related endocrine abnormalities. The smallest clinical deletions fall within the large (∼650Kb) SNHG14 gene, removing 29 consecutive introns that each generate SNORD116. SNHG14 also includes 48 tandem introns encoding ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-15 | PXD057208 | Pride
Small nucleolar rnas Dia Prader-willi syndrome Snord116 Snord115 
GenomicsRoles of SNORD115 and SNORD116 ncRNA clusters during neuronal differentiation
Roles of SNORD115 and SNORD116 ncRNA clusters during neuronal differentiation
PRJNA1162504 | ENA
TranscriptomicsRoles of SNORD115 and SNORD116 ncRNA clusters during neuronal differentiation
In the snoRNA host gene SNHG14, 29 consecutive introns each generate SNORD116, and 48 tandem introns encode SNORD115. Loss of SNORD116 expression, but not of SNORD115, is linked to the neurodevelopmental disease Prader-Willi syndrome. SNORD116 and SNORD115 resemble box C/D small nucleolar RNAs (snoR...
ORGANISM(S): Homo sapiens 
2024-12-05 | GSE277484 | GEO
UnknownRoles of SNORD115 and SNORD116 ncRNA clusters during neuronal differentiation.
Not available
S-EPMC11608373 | biostudies-literature
UnknownSNORD116 and SNORD115 change expression of multiple genes and modify each other's activity.
Not available
S-EPMC5586535 | biostudies-literature
TranscriptomicsEctopic expression of Snord115 in choroid plexus interferes with editing but not splicing of 5-Ht2c receptor pre-mRNA in mice
Serotonin 5-HT2C receptor is a G-protein coupled excitatory receptor that regulates several biochemical pathways and has been implicated in obesity, mental state, sleep cycles, autism, neuropsychiatric disorders and neurodegenerative diseases. The activity of 5-HT2CR is regulated via alternative spl...
ORGANISM(S): Mus musculus 
2021-08-25 | GSE119419 | GEO
UnknownReassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model.
Not available
S-EPMC7673782 | biostudies-literature
OtherRe-assessment of the involvement of Snord115 in the serotonin 2C receptor pathway in a genetically relevant mouse model
SNORD115 has been proposed to promote the activity of serotonin (HTR2C) receptor via its ability to base-pair with its pre-mRNA and regulate alternative RNA splicing and/or A-to-I RNA editing. Because SNORD115 genes are deleted in most patients with the Prader-Willi syndrome (PWS), diminished HTR2C ...
ORGANISM(S): Mus musculus 
2020-10-01 | GSE145159 | GEO
UnknownNeuronal differentiation induces SNORD115 expression and is accompanied by post-transcriptional changes of serotonin receptor 2c mRNA.
Not available
S-EPMC5865145 | biostudies-literature
UnknownEctopic expression of Snord115 in choroid plexus interferes with editing but not splicing of 5-Ht2c receptor pre-mRNA in mice.
Not available
S-EPMC6414643 | biostudies-literature
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