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UnknownIL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer.
Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)-LTβ receptor (LTβR) pathway1, the inflammatory signals...
S-EPMC11864983 | biostudies-literature
UnknownThe structural basis of accelerated host cell entry by SARS-CoV-2†.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the pandemic coronavirus disease 2019 (COVID-19) that exhibits an overwhelming contagious capacity over other human coronaviruses (HCoVs). This structural snapshot describes the structural bases underlying the pan...
S-EPMC7753708 | biostudies-literature
ProteomicsProteomic analysis of Bombus terrestris queen haemolymph
Enabled by recently available genomic resources for bumblebees, nano LC-MS/MS based proteomics was conducted to characterise the queen haemolymph proteome. The resulting mass spectrometry data were also utilised in a proteogenomic capacity to identify proteins missing from official gene sets and to ...
ORGANISM(S): Bombus terrestris (Buff-tailed bumblebee) (Apis terrestris) 
2015-02-24 | PXD001644 | Pride
Bumblebee Proteogenomics Haemolymph profile Queen 
ProteomicsBumblebee venom - The genomes of two key bumblebee species with primitive eusocial organization
This experiment provide a comprehensive overview of proteins present in bumblebee venom.
ORGANISM(S): Bombus terrestris (Buff-tailed bumblebee) (Apis terrestris) 
2015-04-29 | PXD001623 | Pride
Venom Toxing Bumblebee 
UnknownThe genomes of two key bumblebee species with primitive eusocial organization.

Background

The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and th...
S-EPMC4414376 | biostudies-literature
UnknownThe generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags.
Whereas genome sequencing defines the genetic potential of an organism, transcript sequencing defines the utilization of this potential and links the genome with most areas of biology. To exploit the information within the human genome in the fight against cancer, we have deposited some two million ...
S-EPMC263829 | biostudies-literature
UnknownHuman subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.
The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymm...
S-EPMC5540813 | biostudies-literature
UnknownThe genetic architecture of the human cerebral cortex.
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance...
S-EPMC7295264 | biostudies-literature
UnknownPopulation and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Not available
S-EPMC6227915 | biostudies-literature
UnknownGeoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies.

Background

Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient...
S-EPMC8766316 | biostudies-literature
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