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Metabolomicsβ-Hydroxybutyrate Restores Social Deficits via Suppressing HDAC9 in the Anterior Cingulate Cortex of Shank3B-Deficient Mice

Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, yet effective interventions remain limited. Ketogenic diet (KD) shows behavioral benefits in ASD, but the underlying mechanisms remain unclear. Here, using Shank3B knockout (KO) mice, we find that KD induces syst...

2026-07-08 | MTBLS14381 | MetaboLights
MetabolomicsTraditional Chinese medicine Dachaihu decoction alleviates abnormal behavior through regulating gut microbiota and metabolites in children with ASD

Traditional Chinese Medicine Dachaihu decoction (DCHD) has been reported to hold great promise to alleviate autism spectrum disorders (ASD), a generalized neurodevelopmental disease associated with gut microbiome dysbiosis. Health-promoting effects of DCHD on ASD children could be attributed to g...

2025-12-12 | MTBLS13501 | MetaboLights
GenomicsDramatic effects of social behavior on gene regulation in rhesus macaques
This SuperSeries is composed of the following subset Series: GSE33090: Dramatic effects of social behavior on gene regulation in rhesus macaques [Individual_expression] GSE34127: Dramatic effects of social behavior on gene regulation in rhesus macaques [Cell type_expression] GSE34128: Dramatic effec...
ORGANISM(S): Macaca mulatta 
2012-02-01 | E-GEOD-34129 | biostudies-arrayexpress
MetabolomicsNeuropeptide SP protects against colitis and linked anxiety-like behavior via gut microbiota and metabolite inositol: A multi-omics analysis of the gut-brain axis

The gut-brain axis facilitates two-way communication between gut inflammation and psychiatric comorbidities associated with inflammatory bowel disease (IBD). In this study, we examined the neuroprotective effects of the neuropeptide substance P (SP) on colitis. Taking into account the interaction...

2025-11-18 | MTBLS11203 | MetaboLights
TranscriptomicsGenomics of colony founding in fire ants - pleo2
This experiment was performed to investigate the effect of the manipulation of social rank on gene expression. Fire ants newly mated queens were paired and placed in nesting chambers. After emergence of workers, queensM-^R behavior was monitored. Once the behavioral observation revealed the social r...
ORGANISM(S): Solenopsis invicta 
2013-08-21 | E-MEXP-3898 | biostudies-arrayexpress
TranscriptomicsGenotype mixing affects gene expression associated with hygienic behavior
Analysis used total RNA samples of individual brains of low hygienic strain worker bees that were derived from experimental colonies combined of low hygienic genotypes (L pure colonies) resp. low and high hygienic genotypes (L/H mixed colonies). Four-condition experiment: individuals that did perfor...
ORGANISM(S): Apis mellifera 
2012-09-24 | E-MTAB-801 | biostudies-arrayexpress
GenomicsDramatic effects of social behavior on gene regulation in rhesus macaques [Bisulfite seq]
These data are a component of a larger study investigating differences in gene regulation in relationship to rhesus macaque dominance rank. These data compare DNA methylation levels between individuals of different rank on a genome-wide scale using bisulfite sequencing DNA from peripheral blood mono...
ORGANISM(S): Macaca mulatta 
2012-02-01 | E-GEOD-34128 | biostudies-arrayexpress
TranscriptomicsExpression data from ileum of mice suffered from subchronic and mild social defeat stress
This study aimed to investigate the effects of depression on transcriptome in ileum using a subchronic and mild social defeat stress (sCSDS) model. In addition to exhibiting social deficit and hyperphagia-like behavior, the sCSDS mice keep much more water in their body than control mice. In order to...
ORGANISM(S): Mus musculus 
2016-08-03 | E-GEOD-64004 | biostudies-arrayexpress
TranscriptomicsGTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders Organoid
Mice experiment for GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders
2024-04-15 | E-MTAB-13477 | biostudies-arrayexpress
TranscriptomicsGTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders Organoid SC
GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders Organoid SC
ORGANISM(S): Homo sapiens 
2024-06-27 | E-MTAB-13478 | biostudies-arrayexpress
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