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MetabolomicsEarly-life social experiences remodel hippocampal glycerophospholipid metabolism linked to adult memory

Early-life experiences profoundly shape brain development and long-term cognition. Environmental enrichment (EE) and social isolation (SI) represent opposing forms of stimulation and deprivation, yet the metabolic mechanisms connecting these conditions to cognitive outcomes remain poorly defined....

2025-12-04 | MTBLS13454 | MetaboLights
TranscriptomicsTranscription profiling of mouse mammary gland gene expression and tumor growth following chronic social isolation
Clinical studies have revealed that social support improves the outcome of cancer patients while epidemiological studies suggest that social isolation increases the risk of death associated with several chronic diseases. However, the precise biological consequences of an unfavorable social environme...
ORGANISM(S): Mus musculus 
2009-07-11 | E-GEOD-16110 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from animals exposed to social stress
Social stress is well known to be involved in the occurrence and exacerbation of mental illness, and also various life-style related diseases such as hyperinsulinemia, hyperglycemia, cardiovascular diseases and cancer. However, there is little information on tissue-specific gene expression in respon...
ORGANISM(S): Mus musculus 
2009-04-19 | E-GEOD-12693 | biostudies-arrayexpress
GenomicsAcute social isolation alters synaptic plasticity in lateral habenula and social decision
Acute social isolation alters synaptic plasticity in lateral habenula and social decision
PRJNA822836 | ENA
TranscriptomicsTranscription profiling of human peripheral blood leukocytes from CHASRS particpants
Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of soc...
ORGANISM(S): Homo sapiens 
2009-04-23 | E-GEOD-7148 | biostudies-arrayexpress
TranscriptomicsLeukocyte gene expression as a function of perceived social isolation (PSI): Year 7
Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI) Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 62 adults in Year 7 of the Chicago Health Aging and Social Relations Study. ...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-65298 | biostudies-arrayexpress
TranscriptomicsLeukocyte gene expression as a function of perceived social isolation (PSI): Year 10
Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI) Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 100 adults in Year 10 of the Chicago Health Aging and Social Relations Study....
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-65403 | biostudies-arrayexpress
TranscriptomicsLeukocyte gene expression as a function of perceived social isolation (PSI): Year 9
Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI) Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 92 adults in Year 9 of the Chicago Health Aging and Social Relations Study. ...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-65341 | biostudies-arrayexpress
TranscriptomicsLeukocyte gene expression as a function of perceived social isolation (PSI): Year 8
Individual differences in basal leukocyte gene expression profiles as a function of perceived social isolation (PSI) Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 93 adults in Year 8 of the Chicago Health Aging and Social Relations Study. ...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-65317 | biostudies-arrayexpress
ProteomicsThe pupal molting fluid has evolved social functions in ants
Insect societies are tightly integrated, complex biological systems in which group-level properties arise from the interactions between individuals. However, these interactions have not been studied systematically and therefore remain incompletely known. Using a social isolation approach, we discove...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037344 | Pride
Eusociality Development Evolution Parental care behavior Lc-ms Molting Trophallaxis Social fluid Ant pupa Molting fluid 
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