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TranscriptomicsTranscription profiling of mouse Sod2-/- and Sod2+/+ erythroblasts.
The mitochondrial superoxide dismutase (SOD2) is a major antioxidant protein which detoxifies superoxide anion radicals generated by mitochondrial respiration (Weisiger and Fridovich, J. Biol. Chem. 1973). We designed a model of oxidative stress-induced anemia caused by SOD2-deficiency (Friedman et...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-8726 | biostudies-arrayexpress
ProteomicsMass Spectometry Analysis of Inhibition of SOD2-mediated protein degradation
Peptide samples were analysed by a shot-gun approach as described recently (Stieglitz et al., 2022). Raw MS data were processed using Max Quant (version 2.0, Cox and Mann 2008), Perseus software (version 2.0.6.0)(Tyanova et al.,2016), and human entries of uniprot DB. Proteins were stated identified ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-03-15 | MSV000094325 | MassIVE
TranscriptomicsRNA-seq of mouse heart that is both heart SOD2 knockout and deficient for mitochondrial DNA repair
To study whether increase in mitochondrial oxidative stress (SOD2 removal) and decrease in mitochondrial DNA repair (Ogg1 dMTS) results into increase in mutations in mitochondrial RNA (mtRNA). Oxidative stress has been suggested to induce mutations in mtDNA and as DNA is used as a template in transc...
ORGANISM(S): Mus musculus 
2018-07-13 | E-MTAB-6534 | biostudies-arrayexpress
GenomicsDNA-seq of mitochondrial DNA from mouse heart that is both heart SOD2 knockout and deficient for mitochondrial DNA repair
To study whether increase in mitochondrial oxidative stress (SOD2 removal) and decrease in mitochondrial DNA repair (Ogg1 dMTS) results into increase in mitochondrial DNA mutation load. Oxidative stress has been suggested to induce mutations in mtDNA. To verify this, we extracted and sequenced (Illu...
ORGANISM(S): Mus musculus 
2018-07-13 | E-MTAB-6533 | biostudies-arrayexpress
ProteomicsParaquat Exposure and Sod2 Knockdown have Dissimilar Impacts on the Drosophila melanogaster Carbonylated Protein Proteome
Exposure to Paraquat and RNA interference knockdown of mitochondrial superoxide dismutase (Sod2) are known to result in significant lifespan reduction, locomotor dysfunction, and mitochondrial degeneration in Drosophila melanogaster. Both perturbations increase the flux of superoxide, a progenitor r...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2014-11-26 | PXD001528 | Pride
Hcd Protein carbonylation Drosophila melanogaster Orbitrap Itraq 
GenomicsEffect of overexpression of WT-SOD2 and NLS-SOD2 on gene expression of MCF7 breast cancer cells
Effect of overexpression of WT-SOD2 and NLS-SOD2 on gene expression of MCF7 breast cancer cells
PRJNA853782 | ENA
ProteomicsCirculating SOD2 is a Response Biomarker for Neoadjuvant Therapy in Breast Cancer
There is a great need of non-invasive tools that inform of an early molecular response to cancer therapeutic treatment. Here, we have tested the hypothesis that proteolytically resistant proteins could be candidate circulating tumor biomarkers for cancer therapy. Proteins resistant to proteolysis ar...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD032359 | Pride
Proteolysis-resistant proteins Sod2 Biomarker 
TranscriptomicsSod2 KO anemic mice
Gene expression profiling was performed using Anemic Sod 2 Knockout mice and was compared to Gene expression profiles from Sod 2 WT mice. Background: Our laboratory is interested in the role of oxidative stress in aging and human disease. Currently, a major focus of our efforts is the characterizati...
ORGANISM(S): Mus musculus 
2011-02-04 | E-GEOD-27053 | biostudies-arrayexpress
TranscriptomicsExpression Data from Sod2-/- and Sod2+/+ Mouse Erythroblasts.
The mitochondrial superoxide dismutase (SOD2) is a major antioxidant protein which detoxifies superoxide anion radicals generated by mitochondrial respiration (Weisiger and Fridovich, J. Biol. Chem. 1973). We designed a model of oxidative stress-induced anemia caused by SOD2-deficiency (Friedman et ...
ORGANISM(S): Mus musculus 
2008-08-06 | GSE8726 | GEO
ProteomicsMitochondria enriched proteome from heart of heart Sod2 knockout mice LC MS/MS
Superoxide dismutases (SOD) convert superoxide to hydrogen peroxide and therefore provide an important ROS defence mechanism. SOD2 is the sole superoxide dismutase in mitochondrial matrix and thus SOD2 knockout mice can be utilized to analyse what effects increased oxidative stress has on mitochondr...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-06 | PXD008998 | Pride
C57bl/6n Heart Sod2 Superoxide dismutase 2 Mitochondria Mouse Mnsod2 
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