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TranscriptomicsGlobal Analysis of Post-transcriptional Gene Expression in Arsenite-treated Human BJ Fibroblasts
Arsenic is a potent environmental toxin and a cause of numerous health problems. Most studies have assumed that arsenic-induced changes in mRNA levels result from effects on gene transcription. The influence of arsenic on post-transcriptional regulation, another important locus of gene expression ...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-57051 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human p53+ and p53- fibroblasts treated with arsenite reveals exit from arsenite-induced mitotic arrest is p53 dependent
Microarray data from G2-synchronized p53(+) and p53(-) fibroblasts before and after 3 h release from cell cycle blockade in the presence of 5 uM sodium arsenite. Experiment Overall Design: Cells expressing p53 from a tet-off regulated construct were synchronized in G2 with a two-step procedure using...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-7101 | biostudies-arrayexpress
TranscriptomicsSodium arsenite induced gene expression changes in A549 human epithelial lung carcinoma cells
Arsenic is methylated during its metabolism, thereby depleting the intracellular methyl donor S-adenosyl-methionine, which may lead to disturbances in DNA methylation patterns which could lead to altered gene expression Cells were exposed to sodium arsenite (NaAsO2, Sigma) at concentrations of 0.08 ...
ORGANISM(S): Homo sapiens 
2014-09-17 | E-GEOD-44169 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of arsenite
Background: Arsenite is one of the most toxic chemical substances known and is assumed to exert detrimental effects on viability even at lowest concentrations. By contrast and unlike higher concentrations, we here find that exposure to low-dose arsenite promotes growth of cultured mammalian cells. I...
ORGANISM(S): Caenorhabditis elegans 
2013-04-23 | E-GEOD-46257 | biostudies-arrayexpress
TranscriptomicsGene expression responses to chronic low dose arsenite exposure
Arsenic (As) exposure is a significant worldwide environmental health concern. Low dose, chronic arsenic exposure has been associated with higher risk of skin, lung, and bladder cancer, as well as cardiovascular disease and diabetes. While arsenic-induced biological changes play a role in disease p...
ORGANISM(S): Homo sapiens 
2015-05-05 | E-GEOD-60760 | biostudies-arrayexpress
TranscriptomicsRibosome profiling data obtained from HEK293T cells 30 minutes after treatment with arsenite to a final concentration of 40 M-BM-5M
Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eIF2. However, the persistent translation of certain mRNAs is required for deployment of an adequate s...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-55195 | biostudies-arrayexpress
TranscriptomicsSodium arsenite induced DNA methylation changes in A549 human epithelial lung carcinoma cells
Arsenic is methylated during its metabolism, thereby depleting the intracellular methyl donor S-adenosyl-methionine, which may lead to disturbances in DNA methylation patterns Cells were exposed to sodium arsenite (NaAsO2, Sigma) at concentrations of 0.08 M-BM-5M, 0.4 M-BM-5M and 2 M-BM-5M for 1, 2 ...
ORGANISM(S): Homo sapiens 
2014-09-17 | E-GEOD-44173 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skin from K6/ODC animals response to folate deficient diets reveals folate deficiency enhances arsenic effects
We demonstrate that expression of key markers of keratinocyte differentiation is suppressed by exposure to sodium arsenite. Folate deficiency exacerbates this effect. In addition, cancer-related cell movement genes, and growth and proliferation genes are altered. Several redox-sensitive transcrip...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8733 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling in neural differentiated mouse embryonic stem cells (mESCs) under exposure to sodium valproate and sodium arsenite
Studying chemical disturbances during neural differentiation of mES cells has been established as an alternative in vitro testing approach for the identification of developmental toxicants. miRNAs represent a class of small regulatory RNA molecules, which bind to target mRNAs thereby repressing thei...
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-50216 | biostudies-arrayexpress
TranscriptomicsSodium arsenite induced changes in A549 human epithelial lung carcinoma cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-09-17 | E-GEOD-44174 | biostudies-arrayexpress
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