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GenomicsHeteromeric Kv1.2 channels counteract persistent sodium currents in proprioceptive DRG neurons
Heteromeric Kv1.2 channels counteract persistent sodium currents in proprioceptive DRG neurons
PRJNA1170245 | ENA
ProteomicsPeptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants
Harvester ants (genus Pogonomyrmex) are notable for their stings which cause intense, long-lasting pain and other neurotoxic symptoms in vertebrates. Here we show that harvester ant venoms are relatively simple and composed largely of peptide toxins. One class of peptides is primarily responsible fo...
ORGANISM(S): Pogonomyrmex 
2024-06-16 | PXD043773 | Pride
Pain Hymenoptera Venoms Defence Ants 
TranscriptomicsMolecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy: left ventricle DCM
We wanted to see whether the set of affected genes in ischemic cardiomyopathy (ICM) is the same or different as compared to dilated cardiomyopathy (DCM). To find this out, we placed the single DCM sample on the same microarray slide with the ICM samples. Analysis of microarray data with ICM samples ...
ORGANISM(S): Homo sapiens 
2010-06-17 | E-GEOD-17530 | biostudies-arrayexpress
TranscriptomicsHeteromeric Kv1.2 channels counteract persistent sodium currents in proprioceptive DRG neurons
Voltage-gated potassium channels (VGKCs) comprise one of the largest, most diverse and complex families of ion channels. Approximately 70 genes encode the alpha subunits that form homomeric VGKC channels. In addition, these subunits can form functional heteromeric channels, thus exponentially increa...
ORGANISM(S): Mus musculus 
2025-01-02 | GSE279047 | GEO
UnknownMutant bacterial sodium channels as models for local anesthetic block of eukaryotic proteins.
Not available
S-EPMC4954582 | biostudies-literature
TranscriptomicsTranscription profiling of murine neurons in the nodose and dorsal root ganglia to elucidate molecular characteristics of different sensory neorons.
Vagal afferent neurons are thought to convey primarily physiological information, whereas spinal afferents transmit noxious signals from the viscera to the central nervous system. In order to elucidate molecular identities for these different properties, we compared gene expression profiles of neu...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2917 | biostudies-arrayexpress
UnknownA governance of ion selectivity based on the occupancy of the "beacon" in one- and four-domain calcium and sodium channels.
Not available
S-EPMC10120453 | biostudies-literature
UnknownInsect sodium channels and insecticide resistance.
Not available
S-EPMC3052376 | biostudies-literature
GenomicsMicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodium channels in spinal cord
MicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodium channels in spinal cord
PRJNA605099 | ENA
GenomicsWhole exome sequencing in RVOT patients
In a patient with right ventricular outflow tract (RVOT) tachycardia we identified a heterozygous point mutation in the selectivity filter of the stretch-activated K2P potassium channel TREK-1 (KCNK2 or K2P2.1). This mutation introduces abnormal sodium permeability to TREK-1 In addition, mutant chan...
EGAS00001002319 | EGA
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