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MetabolomicsPantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii
Coenzyme A (CoA) is an essential molecule acting in metabolism, post-translational modification, and regulation of gene expression. While all organisms synthesize CoA, many, including humans, are unable to produce its precursor, pantothenate. Intriguingly, like most plants, fungi and bacteria, paras...
2022-03-21 | MTBLS2501 | MetaboLights
ModelsTymoshenko2015 - Genome scale metabolic model - ToxoNet1
Tymoshenko2015 - Genome scale metabolic model - ToxoNet1 This model is described in the article: Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis. Tymoshenko S, Oppenheim RD, Agren R, Nielsen J, Soldati-Favre D, H...
2015-07-07 | MODEL1504280000 | BioModels
ProteomicsIdentification of RON13 binding with with RON4 substrate
Active host cell invasion by the obligate intracellular apicomplexan parasites relies on the formation of a moving junction (MJ), which joins parasite and host cell plasma membranes during entry. Invading Toxoplasma gondii tachyzoites secrete a complex of RON proteins from the rhoptry organelles tha...
ORGANISM(S): Toxoplasma gondii GT1 
2021-05-10 | PXD023791 | Pride
Ron13 Toxoplasma gondii Secretory pathway Hdx-ms Kinase 
ProteomicsStructural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii
The phylum of Apicomplexa groups intracellular parasites that employ substrate-dependent gliding motility to invade host cells, egress from the infected cells and cross biological barriers. The glideosome associated connector (GAC) is a conserved protein essential to this process. GAC facilitates th...
ORGANISM(S): Toxoplasma gondii RH-88 
2023-05-10 | PXD039335 | Pride
Apicomplexa Gliding motility X-ray crystallography Hdx-ms Toxoplasma gondii 
ProteomicsStrucuture-function relationships of an atypical secretory kinase essential for Toxoplasma gondii invasion
An essential step in active host cell invasion by the obligate intracellular apicomplexan parasites is the formation of a moving junction (MJ), which joins both plasma membranes and connects the underlying host cortical cytoskeleton with the parasite actomyosin system. Invading Toxoplasma gondii sec...
ORGANISM(S): Toxoplasma gondii GT1 
2021-05-11 | PXD021516 | Pride
Toxoplasma gondii kinase ron complex invasion 
ProteomicsLFQ of anti-HA IP-MS of PLP1-3HA expressing Toxoplasma
Control (ROP9-3HA) parasites or PLP1-3HA expressing parasites were fixed with 0.1% PFA and lysed in HEPES-RIPA buffer (20 mM HEPES-NaOH, pH 7.5, 1 mM EGTA, 1 mM MgCI2, 150 mM NaCl, 0.25% sodium deoxycholate, 0.05% SDS, 1% NP-40) supplemented with protease inhibitor cocktail cOmplete EDTA-free (Roche...
ORGANISM(S): Cellular Organisms 
2026-03-04 | PXD068211 | JPOST Repository
ProteomicsLFQ of Spot-Trap IP-MS of MIC11-Spot-HA expressing Toxoplasma
∆MIC11::MIC11-Spot-HA parasites or the parental ∆MIC11 parasites were fixed with 0.1% PFA and lysed in HEPES-RIPA buffer (20 mM HEPES-NaOH, pH 7.5, 1 mM EGTA, 1 mM MgCl2, 150 mM NaCl, 0.25% sodium deoxycholate, 0.05% SDS, 1% NP-40) supplemented with protease inhibitor cocktail cOmplete EDTA-free (Ro...
ORGANISM(S): Cellular Organisms 
2026-03-04 | PXD062810 | JPOST Repository
ProteomicsTgondii - Whole organism, iBAQ (Kloehnetal,bmcbiol2020)
abundance based on iBAQ, Interaction consistency score: 4.8, Coverage: 6
ORGANISM(S): 5811 
2020-00-00 | 2899534466 | PAXDB
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