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MetabolomicsCTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function...
2022-06-14 | MTBLS2851 | MetaboLights
UnknownThe UCMD-Causing <i>COL6A1</i> (<i>c</i>.930 + 189<i>C</i> > <i>T</i>) Intron Mutation Leads to the Secretion and Aggregation of Single Mutated Collagen VI <i>α</i>1 Chains.
Not available
S-EPMC11919215 | biostudies-literature
TranscriptomicsLoss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis (Affymetrix)
DNA methylation is tightly regulated throughout mammalian development and altered methylation patterns are a hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in acute myeloid leukemia (AML) and has been suggested to protect CpG islands and promoters from aberrant methyla...
ORGANISM(S): Mus musculus 
2015-04-22 | E-GEOD-59586 | biostudies-arrayexpress
Transcriptomicsangiogenesis course
This is a time course experiment with 4 - 6 slides per time point where all samples were hybridised to time zero. The microarray slides were scanned using a GenePix 4000B Scanner (Axon Instruments, Foster City, CA, USA). The â??SPOTâ?? software package (CSIRO) was used to identify spots and subtrac...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-779 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of chronic myelogenous leukemia (CML) and normal, quiescent and dividing haematopoietic cells
Quiescent and dividing hemopoietic stem cells (HSC) display marked differences in their ability to move between the peripheral circulation and the bone marrow. Specifically, long-term engraftment potential predominantly resides in the quiescent HSC subfraction, and G-CSF mobilization results in the ...
ORGANISM(S): Homo sapiens 
2014-04-25 | E-MTAB-2508 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung from wildtype and glucocorticoid recepter knockouts to investigate investigate the role of glucocorticoids in fetal lung development
The aim of this experiment is to investigate the role of glucocorticoids in fetal lung development in more detail.
ORGANISM(S): Mus musculus 
2007-05-31 | E-MEXP-861 | biostudies-arrayexpress
UnknownEffect of an exercise intervention on gestational diabetes mellitus: a randomized controlled trial.
Not available
S-EPMC4418021 | biostudies-literature
UnknownCharacterization of severe COL6-related dystrophy due to the recurrent variant COL6A1 c.930+189C>T.
Not available
S-EPMC12404708 | biostudies-literature
TranscriptomicsCole Lab Fred- genotypeRA experiment
Mammalian lung development during the saccular and alveolar stages is dependent upon antagonistic molecular signalling by endogenous retinoic acid (RA) and glucocorticoids (GCs) which regulate gene expression via the retinoic acid receptor (RAR) family and the glucocorticoid receptor (GR), respectiv...
ORGANISM(S): Mus musculus 
2014-01-12 | E-MEXP-3833 | biostudies-arrayexpress
TranscriptomicsGlobal regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR) [expression]
Alternative mRNA splicing is a major mechanism for gene regulation and transcriptome diversity. Despite the extent of the phenomenon, the regulation and specificity of the splicing machinery are only partially understood. Adenosine-to-inosine (A-to-I) RNA editing of pre-mRNA by ADAR enzymes has been...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-47945 | biostudies-arrayexpress
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