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TranscriptomicsEffects of mutation in a soluble guanylyl cyclase gene
Genomic and behavioral investigations were performed to determine the effects of a mutation in a Drosophila soluble guanylyl cyclase gene. A mutant DGCalpha1[3] third chromosome was crossed into a natural rover (for[R]) or natural sitter (for[s]) genetic background. (See Osborne et al. 1997; PMID: ...
ORGANISM(S): Drosophila melanogaster 
2010-06-10 | E-GEOD-2136 | biostudies-arrayexpress
ProteomicsSoluble guanylyl cyclase mediates noncanonical nitric oxide signaling by nitrosothiol transfer under oxidative stress
Soluble guanylyl cyclase (GC1) is an α/β heterodimer producing cGMP when stimulated by nitric oxide (NO). The NO-GC1-cGMP pathway is essential to cardiovascular homeostasis but is disrupted by oxidative stress, which induces GC1 desensitization to NO by S-nitrosation (SNO) of its cysteines (C). We d...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-10-15 | PXD033105 | Pride
Nitric oxide S-nitrosylation Cgmp S-nitrosation Oxidative stress Soluble guanylyl cyclase 
GenomicsGenes regulated by soluble guanylyl cyclase in VCaP prostate cancer cells
Genes regulated by soluble guanylyl cyclase in VCaP prostate cancer cells
PRJNA472401 | ENA
TranscriptomicsGenes regulated by soluble guanylyl cyclase in VCaP prostate cancer cells
The aberrant activation of the ERG oncogenic pathway due to TMPRSS2-ERG gene fusions is the major driver of prostate cancer initiation and progression. We identified the alpha1 and beta1 subunits of soluble guanylyl cyclase (GUCY1A1, GUCY1B1) as major ERG-regulated genes in prostate cancer cells. So...
ORGANISM(S): Homo sapiens 
2018-05-22 | GSE114738 | GEO
TranscriptomicsEffects of mutation in a soluble guanylyl cyclase gene
Genomic and behavioral investigations were performed to determine the effects of a mutation in a Drosophila soluble guanylyl cyclase gene. A mutant DGCalpha1[3] third chromosome was crossed into a natural rover (for[R]) or natural sitter (for[s]) genetic background. (See Osborne et al. 1997; PMID: 9...
ORGANISM(S): Drosophila melanogaster 
2005-05-01 | GSE2136 | GEO
ModelsStone1996 - activation of soluble guanylate cyclase by nitric oxide
Stone1996 - activation of soluble guanylate cyclase by nitric oxide This features the two step binding of NO to soluble Guanylyl Cyclase as proposed by Stone JR, Marletta MA. Biochemistry (1996) 35(4):1093-9 . There is a fast step binding scheme and a slow step binding scheme. The difference lies i...
2024-09-02 | BIOMD0000000198 | BioModels
TranscriptomicsIdentification of Notch targets in human endothelial cells
Human umbilical vein endothelial cells (HUVECs) were transduced with either MIY-N1IC (Notch1 intracellular domain) or MIY vector control. The cells were sorted for YFP, and RNA was extracted using Trizol (Invitrogen) and analyzed by the Affymetrix Human Genome U133 Plus 2.0 Array. Results were analy...
ORGANISM(S): Homo sapiens 
2011-06-09 | E-GEOD-29850 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HUVEC cells exposed to 250 uM DETA-NONOate for 4 hours in the presence and absence of 10 uM of the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo-[4,3,2]quinoxalin-1-one (ODQ)
HUVECs were exposed to 250 uM DETA-NONOate for 4 hours in the presence and absence of 10 uM of the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo-[4,3,2]quinoxalin-1-one (ODQ). Control cells were exposed to vehicle (methanol 0.1%).
ORGANISM(S): Homo sapiens 
2005-04-01 | E-UMCU-7 | biostudies-arrayexpress
UnknownThe Dictyostelium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase.
Not available
S-EPMC125260 | biostudies-literature
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