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ProteomicsG3BP1-linked mRNA partitioning supports selective protein synthesis in response to oxidative stress
Cells limit energy-consuming mRNA translation during stress to maintain metabolic homeostasis. Sequestration of mRNAs by RNA binding proteins (RBPs) into stress granules (SGs) reduces translation, but it remains unclear whether SGs also function in partitioning of specific transcripts to polysomes (...
ORGANISM(S): Homo sapiens (Human) 
2020-04-30 | PXD015491 | Pride
Prostate cancer Apex G3bp1 Stress granules 
ProteomicsPhase separation and stress granule association of SARS-CoV-2 Nucleocapsid protein
The current work identified the protein interactors of SARS-CoV-2 Nucleocapsid RNA binding protein (NCAP or N protein) in lung cancer A-549 cells, using a co-immunoprecipitation strategy, which is coupled with SILAC-based mass spec. A significant proportion of the identified NCAP interacting protein...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD023989 | Pride
Silac mass spec Ncap Nucleocapsid Sars-cov-2 
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