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ProteomicsG3BP1-linked mRNA partitioning supports selective protein synthesis in response to oxidative stress
Cells limit energy-consuming mRNA translation during stress to maintain metabolic homeostasis. Sequestration of mRNAs by RNA binding proteins (RBPs) into stress granules (SGs) reduces translation, but it remains unclear whether SGs also function in partitioning of specific transcripts to polysomes (...
ORGANISM(S): Homo sapiens (Human) 
2020-04-30 | PXD015491 | Pride
Prostate cancer Apex G3bp1 Stress granules 
ProteomicsNorovirus infection results in assembly of virus-specific G3BP1 granules and evasion of eIF2 apha signaling
Proteomic analysis of murine stress granule and G3BP1 granulome in infected cells. BV2 GFP-G3BP1 cells were either treated with 0.1 mM arsenite for 1h to induce SG assembly or infected with MNV for 9h. G3BP1 granules were enriched by sequential centrifugation and purified by immunoprecipitation usi...
ORGANISM(S): Mus musculus (Mouse) 
2019-12-12 | PXD011956 | Pride
Stress granules G3bp1 Arsenite Mnv 
ProteomicsIdentification of lncRNA CALA-dependent protein interaction partners of G3BP1 in the cytoplasm
We previously identified the stimuli-responsive lncRNA CALA to impact endothelial cell function and identified G3BP1 as a main interaction partner of CALA in the cytoplasm of human umblical vein endothelial cells (HUVECs). To uncover the role of the lncRNA CALA in G3BP1-RNPs in the cytoplasm, we pur...
ORGANISM(S): Homo sapiens (Human) 
2022-07-04 | PXD033517 | Pride
Lncrna-dependent protein/protein interaction 
ProteomicsMass spectrometry characterization of O-GlcNAc modification of GFP-tagged G3BP1
This dataset contains mass spectrometry data generated to characterize O-GlcNAc modification of human G3BP1 expressed as an N-terminal EGFP fusion in H9c2 cardiac cells. EGFP-G3BP1 was overexpressed by adenoviral transduction, affinity purified using GFP-Trap, resolved by SDS-PAGE, and the band corr...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2026-09-28 | PXD083651 | Pride
Post-translational modification Stress granules H9c2 O-glcnacylation Ethcd Hcd G3bp1 O-glcnac Hexnac Egfp Lc-ms/ms 
ProteomicsG3BP1 Ribonucleoprotein Complexes Regulate Focal Adhesion Protein Mobility and Cell Migration
The subcellular localization of mRNAs plays a pivotal role in biological processes, including cell migration1-6. For instance, β-actin mRNA and its associated RNA binding protein (RBP), ZBP1/IGF2BP1, are recruited to focal adhesions (FAs), to support localized β-actin synthesis, crucial for cell mig...
ORGANISM(S): Homo sapiens (Human) 
2025-01-22 | PXD059392 | Pride
Lc-ms 
ProteomicsThe interactome of G3BP1 in UMUC3 cells
The HA-tagged G3BP1 complex was obtained by co-IP with anti-HA antibodies from UMUC3 cells stably expressing HA-tagged G3BP1. The purified immunoprecipitants were resolved on gradient SDS-PAGE, silver-stained, and subjected to MS analysis.
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD035722 | Pride
Bladder cancer G3bp1 Umuc3 
GenomicsG3BP1 translocates into mitochondria to impair MCU complex function and promotes NASH progression [G3bp1-HKO and G3bp1-Flox mice with BSA or PA treatment]
G3BP1 translocates into mitochondria to impair MCU complex function and promotes NASH progression [G3bp1-HKO and G3bp1-Flox mice with BSA or PA treatment]
PRJNA1147585 | ENA
GenomicsG3BP1 Binds to Guanine Quadruplexes in mRNAs
G3BP1 Binds to Guanine Quadruplexes in mRNAs
PRJNA714642 | ENA
ProteomicsInteractome of G3BP1 in C9ORF72-ALS
Interactome of G3BP1 in C9ORF72 hexanucleotide repeat expansion carrying iPSC derived motor neurons
ORGANISM(S): Homo sapiens (Human) 
2025-06-25 | PXD065424 | Pride
C9orf72 Stress granules Als G3bp1 
GenomicsChIP-seq analysis of G3BP1 in KGN cells
ChIP-seq analysis of G3BP1 in KGN cells
PRJNA1098015 | ENA
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