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TranscriptomicsNascent-seq indicates widespread cotranscriptional RNA editing in Drosophila
The RNA editing enzyme ADAR chemically modifies adenosine (A) to inosine (I), which is interpreted by the ribosome as a guanosine. Here we assess cotranscriptional A-to-I editing in Drosophila, by isolating nascent RNA from adult fly heads and subjecting samples to high-throughput sequencing. There ...
ORGANISM(S): Drosophila melanogaster 
2012-05-31 | E-GEOD-37232 | biostudies-arrayexpress
ProteomicsProteome analysis of skeletal muscle samples from a porcine model of Duchenne muscular dystrophy treated by somatic gene editing
Duchenne muscular dystrophy (DMD) is caused by genetic deficiency of dystrophin and characterized by massive structural and functional changes of skeletal muscle tissue, leading to terminal muscle failure. In this project, proteomics data from skeletal muscle of a genetically engineered DMD pig mode...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-02-05 | PXD014893 | Pride
Porcine model Duchenne muscular dystrophy Somatic gene editing 
UnknownImpacts of RNA Mobility Signals on Virus Induced Somatic and Germline Gene Editing.
Not available
S-EPMC9219249 | biostudies-literature
TranscriptomicsTranscriptome sequencing of human hepatocellular carcinoma
Deep high-throughput transcriptome sequencing (RNA-seq) performed on 3 pairs of matched tumor and adjacent non-tumorours (NT) tissues from HCC patients of Chinese origin generated 183.6-million reads that could be aligned. We discovered a number of differentially expressed genes and multiple types o...
ORGANISM(S): Homo sapiens 
2013-04-02 | E-GEOD-33294 | biostudies-arrayexpress
GenomicsEfficient and multiplexed somatic genome editing with Cas12a mice
Efficient and multiplexed somatic genome editing with Cas12a mice
PRJNA1210636 | ENA
TranscriptomicsUbiquitous expression of long dsRNA in mice causes mainly RNAi effects in the oocyte
Double-stranded RNA (dsRNA) can enter different pathways in mammalian cells, such as the sequence-specific RNA interference (RNAi) pathway, the sequence-independent interferon response, and RNA editing by adenosine deaminases. To study routing of long dsRNA into different pathways in different tissu...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-26577 | biostudies-arrayexpress
UnknownSomatic Gene Editing of GUCY2D by AAV-CRISPR/Cas9 Alters Retinal Structure and Function in Mouse and Macaque.
Not available
S-EPMC6534089 | biostudies-literature
TranscriptomicsGenetic stability in FA cells before and after gene editing and cell reprogramming.
Fibroblasts from a Fanconi anemia (FA) patient  (FA-52) before and after correction by gene editing and transduction with a lentiviral vector expressing telomerase (geFA-52T fibroblasts). IPCs were generated from fibroblasts corrected by gene editing using STEMCCA LV (geFA-52T IPSCs clone 16) and fi...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-56790 | biostudies-arrayexpress
UnknownFast-TrACC: A Rapid Method for Delivering and Testing Gene Editing Reagents in Somatic Plant Cells.
Not available
S-EPMC8344638 | biostudies-literature
UnknownGene Editing and Genotoxicity: Targeting the Off-Targets.
Not available
S-EPMC8525370 | biostudies-literature
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