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ProteomicsProteogenomics Connects Somatic Mutations to Signalling in Breast Cancer
Explore This Study at the NCI Proteomic Data Commons

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2019-08-28 | MSV000084248 | MassIVE
TranscriptomicsTranscription profiling of human lung adneocarcinomas - discovery of somatic mutations in lung adenocarcinomas
This was a collaborative study to discover somatic mutations in 188 lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high...
ORGANISM(S): Homo sapiens 
2009-09-11 | E-GEOD-12667 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine
This SuperSeries is composed of the following subset Series: GSE29996: Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine [Affymetrix SNP array data] GSE29998: Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medici...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-29999 | biostudies-arrayexpress
TranscriptomicsEZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B-cells and targeted by somatic mutations in B-cell lymphomas. Here we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions in mice. EZH2 represses proliferation checkpoint genes and h...
ORGANISM(S): Homo sapiens 
2013-05-13 | E-GEOD-45982 | biostudies-arrayexpress
GenomicsLayer-specific somatic mutations in apricot
Layer-specific somatic mutations in apricot
PRJEB71142 | ENA
GenomicsAcquisition of somatic activating mutations in the vegf-pathway in cardiac angiosarcomas
Study of genetic landscape (germinal and somatic) of cardiac angiosracomas with or without mutations in POT1 gene.
ORGANISM(S): Homo sapiens 
2019-06-03 | E-MTAB-7999 | biostudies-arrayexpress
TranscriptomicsWhole-exome sequencing identifies mutations of BCOR in acute myeloid leukemia with normal karyotype
Among acute myeloid leukemias (AML) with normal karyotype (CN-AML), NPM1 and CEBPA mutations define WHO provisional entities accounting for ~60% of cases, but the remaining ~40% remains poorly characterized. By whole exome-sequencing (WES) of one CN-AML patient lacking mutations in NPM1, CEBPA, FLT3...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-30442 | biostudies-arrayexpress
TranscriptomicsNovel mutations target distinct subgroups of medulloblastoma.
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups. To identify mutations that drive medulloblastoma we sequenced the entire genomes of 37 tumours and matched normal blood. One hundred and thirty-six genes harbouring somatic mutations in this discovery set wer...
ORGANISM(S): Homo sapiens 
2012-07-05 | E-GEOD-37418 | biostudies-arrayexpress
ProteomicsFunctional analysis of somatic variants found in endometrial tumor-specific ER-alpha enhancers
Biological implications of healthy- and tumor-specific ERα cistromes in endometrial tumors have largely been understudied. Moreover, the functional impact of non-coding somatic variants has commonly been underexplored and remained elusive. This study is aimed to provide functional interpretation of ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-15 | PXD029822 | Pride
Enhancers Endometrial cancer Er-alpha Somatic variants 
TranscriptomicsUltra-deep sequencing of plasma DNA identifies druggable mutations in hepatocellular carcinoma
The purpose of the study is to detect somatic mutations in hepatocellular carcinoma using circulating free-DNA. We used deep-sequencing data of a panel of 60 commonly mutated genes in hepatocellular carcinoma.
ORGANISM(S): Homo sapiens 
2018-04-29 | E-MTAB-5123 | biostudies-arrayexpress
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