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ProteomicsProteome characterization of germ cell tumor-related somatic-type malignancies for the identification of tissue origin, cisplatin resistance mechanisms, and putative therapeutic options
Germ cell tumors (GCT) can be distinguished into seminoma and non-seminoma. The latter comprises embryonal carcinoma, which can further differentiate into choriocarcinoma, teratoma (TER), and yolk-sac tumors (YST). However, GCT can transform into a somatic-type malignancy (STM), eventually resulting...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039546 | Pride
Somatic-type malignancy Yolk-sac tumors Germ cell tumors Therapy resistance 
TranscriptomicsHuman lung epithelial cells progressed to malignancy through specific oncogenic manipulations
We have developed cdk4/hTERT-immortalized normal human bronchial epithelial cells (HBECs) to study lung cancer pathogenesis. By studying the oncogenic effect of common lung cancer alterations (p53, KRAS, and c-MYC) we demonstrate the ability of this model to characterize the stepwise transformation...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-40828 | biostudies-arrayexpress
UnknownCase Report: The Complete Remission of a Mixed Germ Cell Tumor With Somatic Type Malignancy of Sarcoma Type With a GCT-Oriented Therapy: Clinical Findings and Genomic Profiling.
Not available
S-EPMC8008106 | biostudies-literature
TranscriptomicsGene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy (testing dataset)
The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of p53-dependent pathway are common hallmarks of aggressive, poor prognostic human cancers,...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-19616 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy (training dataset)
The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of p53-dependent pathway are common hallmarks of aggressive, poor prognostic human cancers,...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-11990 | biostudies-arrayexpress
UnknownThe decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors: report of 2 cases.
Not available
S-EPMC7382836 | biostudies-literature
GenomicsSmall cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4
Small cell carcinoma of the ovary of hypercalcemic type (SCCOHT) is an extremely rare, aggressive cancer affecting children and young women. We identified germline and somatic inactivating mutations in the SWI/SNF chromatin-remodeling gene SMARCA4 in 75% (9/12) of SCCOHT patients in addition to SMAR...
EGAS00001000714 | EGA
GenomicsDiscriminating activities of DEAD-Box Helicase 41 from myeloid malignancy-associated germline variants by genetic rescue
Discriminating activities of DEAD-Box Helicase 41 from myeloid malignancy-associated germline variants by genetic rescue
PRJNA859810 | ENA
TranscriptomicsGene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis
Pathogenesis and factors for determining progression of alcoholic and non-alcoholic steatosis to steatohepatitis with risk of further progression to liver cirrhosis and cancer are poorly understood. In the present study, we aimed to identify potential molecular signatures for discrimination of steat...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-33814 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon cancer sphere cells and parental control cells to study the role of epithelial-mesenchymal transition regulators in tumor malignancy
Isolation and enrichment of cancer stem cells in colorectal carcinoma to study role of epithelial-mesenchymal transition regilators in tumor malignancy. Experiment Overall Design: Genome-wide comparision in sphere cells and parental control cells revealed potential regulators involved tumor malignan...
ORGANISM(S): Homo sapiens 
2009-10-16 | E-GEOD-14773 | biostudies-arrayexpress
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